Real Talk With Jimmy Moore & Dr. Will Cole

Veteran health podcaster, blogger, and international bestselling author (Keto Clarity and The Ketogenic Cookbook) Jimmy Moore from "Livin' La Vida Low-Carb" and Pittsburgh, PA-based functional medicine practitioner Dr. Will Cole from discuss the current health headlines, dissect the latest medical and nutritional health research studies, and answer listener-submitted questions about the low-carb, high-fat, ketogenic diet. Submit your keto questions at
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Real Talk With Jimmy Moore & Dr. Will Cole







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May 28, 2020

Episode 168

It’s Thursday and that means another action-packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today we bring you a special presentation we call the Methylationcast!

“Methylation happens about a billion times every second in the body, but we still don’t understand the totality of it, not even close.”

- Dr. Will Cole

“DNA testing is so accessible to the general public now. This information is accessible to just about everyone now.”

- Jimmy Moore

In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom.

Your genetics influence almost every aspect of your health. Everything from your weight, mood, hormones, and immune system can be traced back to your DNA. As humans we want to know as much about ourselves as possible and because of this the demand for direct-to-consumer genetic testing has grown. For only $100 you can get a kit delivered right to your house for you to send in and get a complete summary of your genetics and ancestry. You can identify distant cousins around the world and conclude what percentage Neanderthal you are because really, who doesn’t want to know that?!

As a functional medicine practitioner Dr. Cole is less concerned with your particular ethnic heritage and more with what role genetics play in your health and how knowing your DNA can make you aware of your risk factors for certain illnesses. But are these tests really worth it or just an easy way for the health industry to make a few dollars? Let’s find out by first looking at the two most popular tests:

3. CBS
5. MAO
8. VDR
9. Detox genes

May 21, 2020

Episode 167

“That’s not to say you can’t enjoy breakfast. The reality is that if you enjoy that, you should not feel shame for getting up and cooking breakfast.”

-Dr. Will Cole

“Even in Ketotarian you didn’t say to eat all the vegetables all the time. You encouraged people to eat what they like.”

-Jimmy Moore

Featured News Headline:
Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet

Today we tackle some of the most common diet myths and how to address them, including:


  • If it tastes good, spit it out
  • Eat everything in moderation as part of a balanced diet (no deprivation)
  • Breakfast is the most important meal of the day
  • I fell off the wagon so I failed on my diet
  • You’ll gain 25 pounds between Thanksgiving and Christmas
  • No pain no gain
  • You need to be a little bit hungry if you want to lose weight
  • Eat lots of small meals throughout the day to boost your metabolism
  • It’s all about calories in, calories out (eat less, move more)
  • I must not have enough willpower
  • The calories you eat on your birthday (or any holiday) don’t count
  • There’s no reason to diet because 95% of the people who do gain back all the weight and then some
  • I must be big-boned and the wrong body type to lose weight
  • All my family has obesity and diabetes, so it must be genetic that I will too
  • I’ll start my diet tomorrow
  • You are what you eat
  • I can’t have that
May 13, 2020

Episode 166

It’s Thursday and that means another action-packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. We are all looking for ways to optimize our health and today we look at common deficiencies everyone can optimize.

“I think it shows how blessed we are in life when this is shaking us compared to what others have suffered with.”

– Dr. Will Cole

“There are moments when I want something, and I will allow ONE MEAL. Then I get right back on plan. Don’t let one slip up turn into a three-week binge.”

– Jimmy Moore

In this unprecedented time of quarantine and social distancing, we are all looking for ways to optimize our health. Dr. Will Cole specializes in this very thing in his daily functional medicine practice helping people dial in their optimal health. In this episode Will and Jimmy talk about the most common nutrient deficiencies and how you can optimize your health in these areas. Just because life has changed doesn’t mean we can’t do everything we can to ensure we’re getting the most from our health.

May 7, 2020

Episode 165

It’s Thursday and that means another action-packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today ask an important question: How can all the various camps in nutrition work together?

“Atkins is the granddaddy of them all and set the stage for all of these to come along.”

– Jimmy Moore

“My top patient base include engineers, nurses, and teachers; people that love data and spreadsheets.”

– Dr. Will Cole

If you are health-minded for very long, you have probably watched the progression and evolution of nutrition. With the advent of the Atkins Diet in the 1970s, Dr. Atkins brought to the mainstream the idea that we should question the status quo of nutrition education. He showed us that carbohydrates were doing us more harm than good. Along the way we have seen other variations on this same way of thinking that brought us the Paleo way of eating, Whole 30, Keto, and now Carnivore.

Listen in today as Jimmy and Will have a fascinating conversation and bring you some real-world information on how to incorporate the best of all these protocols and get the benefits they all bring to your health.

Apr 30, 2020

Episode 164

It’s Thursday and that means another action-packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today we do a deep dive into the endocrine system and talk about the role of hormones on our health.

“It’s cool to see the business side of farming and I think more of us need to get involved to see how we can support our farmers.”

– Dr. Will Cole

“Most of the local farmers want to feed you. Negotiate with them, I guarantee that most of those farmers will work with you.”

– Jimmy Moore

On REAL TALK we love to do specialty discussions where we do a deep dive on a specific topic (PoopcastFunctional Medicine labs, etc.), and today we turn our attention to the endocrine system. As we all who eat a low-carb, ketogenic diet knows, our food has an enormous impact on our hormones.

Listen in today as Jimmy and Will talk about some topics that are in the news then turn their attention to the endocrine system, what hormones are, what labs you should have run, what optimal levels are, and so much more.

Apr 23, 2020

Episode 163
It’s Thursday and that means another action-packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today we get a candid conversation between two international best-selling authors as they share insights into how to be a successful author.

“My brain never stops thinking of new ideas. Between my work with JIMMY RANTS, new book ideas, and podcasting, I never stop thinking of ways to innovate.”

– Jimmy Moore

“I always loved health and I was a writing nerd as well. This was a natural fit for me. It was my writing and my online work that helped launch my telemedicine career.”

– Dr. Will Cole

Listener QuestionThis week’s REAL TALK: Ask Me Anything question that kicks off the show.

Have you ever thought about becoming an author? Do you feel like you have something to say to the world? Well, there was a time when both of our REAL TALK co-hosts felt that way, too before becoming international best-selling authors and sought-after speakers in the health space. Listen in today as Jimmy and Will share their stories of how they both dreamed of becoming published authors and how they stepped out and put feet to their dreams, challenges they encountered along the way, how they use this platform to advance their message, what the editorial process is like, and so much more!

Apr 16, 2020

Episode 162

It’s Thursday and that means another action packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today we look at strategies to combat and avoid the increase in negativity online.

“You have to focus on the positive. Anything that is edifying and lifting up others is what I try to focus on. You also have to be humble and teachable and learn from honest criticism.”

- Dr. Will Cole

“This is my 15th anniversary with Livin’ La Vida Low-Carb, I’ve heard every brand of negativity that has come along.”

- Jimmy Moore

As most of us are sheltering in place and stuck at home, emotions are at an all time high. With the prevalence of social media, it’s easier than ever to vent those frustrations online. We see flame wars erupting over all sorts of topics, and inevitably we find ourselves at odds with one another. What do we do to combat this flood of negative emotions and being sucked into the negativity?

Listen in today as Jimmy and Will share some insight into how you can manage the stress that can lead to the negativity we find in our online lives. What things are you doing to manage the stress in your life right now?

Apr 9, 2020

Episode 161

It’s Thursday and that means another action packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Today we look at how you can boost your immune system without breaking the bank.

“With holidays coming up for a lot of organized religions, we are finding ourselves in a “new abnormal”.

– Dr. Will Cole

“I am making an effort to get plenty of sunshine and taking a high dose of Vitamin-D. I feel like that is serving me very well.”

– Jimmy Moore

“Food is foundational for a healthy immune system. All of the things we’ve been talking about for years on Keto Talk are the things you should be doing to build your immune system.”

– Dr. Will Cole

“De-stressing with things like meditation, exercise, good sleep, etc. I would think would be a huge factor in keeping your immune system working well.”

– Jimmy Moore

As we are all doing our part to try to “flatten the curve” of the Covid-19 outbreak, we find ourselves at home and cut off from our normal routines. Some of us find that our normal sources for healthy food and activities has been disrupted. Many people find that their finances are pinched right now without the ability to go about our normal day to day activities. How do you maintain a healthy lifestyle and boost your immune system while money is tight?

Listen in today as Jimmy and Will look at ways to not just survive, but thrive during this trying time and answer some of your listener questions.

Apr 2, 2020

Episode 160

It’s Thursday and that means another action packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Dr. Keith Berkowitz joins us to talk about a protocol for treating Covid-19 that he believes is being underused right now.

“Inflammation is the real problem with all disease. The virus doesn’t kill many people, it’s the inflammation.”

– Dr. Keith Berkowitz

“Those of us that don’t have Covid-19 need to be doing everything we can to support our immune system.”

– Dr. Will Cole

“This underscores why nutrient density is so important in our diets.”

– Jimmy Moore

Keith Wayne Berkowitz, M.D., is the Founder and Medical Director of the Center for Balanced Health. He combines expertise in both traditional and complementary medicine. Prior to starting the Center for Balanced Health, he was the Medical Director and Business Director of The Atkins Center for Complementary Medicine. He was an associate of Dr. Robert C. Atkins since 1999.

Listen in today to hear Jimmy and Will talk with Dr. Berkowitz about a promising new protocol for treating Covid-19. This promising new treatment is showing tremendous hope and getting results like nothing else we’ve seen thus far. Be sure to share this good news with everyone you know and let’s share some hope in this trying time.

Mar 26, 2020

It’s Thursday and that means another action packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Did you see the controversial comments Dr. Paul Saladino tweeted a few weeks ago? We talk to him about it today.

“You don’t have to be triggered. Listen to the message.”

– Dr. Will Cole

“I’ve been doing this for 15 years and I’ve seen lots of propaganda. People can learn to see through this stuff.”

– Jimmy Moore

“The general M.O. of that show is to make the doctors on that show look valiant. It was a total setup.”

– Dr. Paul Saladino

Dr. Saladino is the leading authority on the science and application of the carnivore diet. He has used this diet to reverse autoimmunity, chronic inflammation and mental health issues in hundreds of patients, many of whom had been told their conditions were untreatable. In addition to his personal podcast, Fundamental Health, he can be found featured on numerous podcasts including The Minimalists, The Model Health Show, Bulletproof Radio, The Dr. Gundry Podcast, The Ben Greenfield Podcast, Dr. Mercola, Health Theory, Mark Bell’s Power Project, and many others. He has also appeared on The Doctors TV show and authored the bestselling book, “The Carnivore Code: Unlocking the Secrets to Optimal Health by Returning to our Ancestral Diet.”

Listen in today as Jimmy and Will talk with Dr. Saladino about his controversial comments fat people and who should and should not be able to talk about health. This show is guaranteed to spark the realest talk about health you’ll hear this week!

Mar 19, 2020

Real Talk Episode 158

It’s Thursday and that means another action packed episode of the realest talk on the internet–Real Talk with Jimmy Moore and Dr. Will Cole. Does the latest news about COVID-19 have you stressed? This episode is for you!

“Even in the midst of this very real human relationship stuff happens.”

– Jimmy Moore

“For most of us if we are not sick, we should use this time as time for meditation and to practice acceptance of things we cannot change.”

– Dr. Will Cole

In this time when we are drawn to watching the news of escalating closures and responses to the COVID- 19 Coronavirus, we find ourselves in the midst of a lot of uncertainty. If you allow your imagination to run away, it’s easy to assume the worst and to play out worst case scenarios in our minds. On today’s show, Jimmy and Dr. Cole talk about dealing with these and share practical advice on what we can do so that we don’t end up feeling the effects of this pandemic years down the road.

Mar 12, 2020

Episode 157

We’re back with another episode of Real Talk with Jimmy Moore and Dr. Will Cole. Today we talk all about the much feared Coronavirus on Episode 157.

“Look how many people die from the common flu compared to what we’ve seen with this virus.”

– Jimmy Moore

“There’s a lot of hysteria that is driving this, especially when you take the information without context.”

– Dr. Will Cole

If you’ve watched the news lately surely you’ve seen the coverage of the Coronavirus (COVID-19). How do you separate the fact from the overhyped fiction? What is the difference in living in fear and being prepared? Is washing your hands enough to fight this global pandemic?

In this episode of Real Talk, Jimmy and Dr. Will Cole cut through the hype and give you some real world advice on navigating this latest news maker.

Mar 5, 2020

Real Talk Episode 156

Today marks the return of Dr. Will Cole and Jimmy Moore from a six-month break, now with a new name: Real Talk!

Jimmy and Will are excited to be back and share the concept behind the show’s new title and expanded focus. While still discussing Keto topics, we’ll also be covering other aspects of life that can have an impact on health and fitness, focusing on Real life!

I am rebranding myself as “The Man Of Real” because I don’t think we have enough reality online…

– Jimmy Moore

The only way we can start to heal is to start talking about it.

– Dr. Will Cole
Aug 29, 2019
episode 155

Today is the last Keto Talk that we bring you before Jimmy heads out for his six month sabbatical. In this special episode, Jimmy and Will go over the battery of tests that Jimmy had done before leaving.

Listen in to this special farewell (for now) episode as Dr. Cole takes a deep look at the functional medicine tests performed by Dr. Gus Vickery. Will gives his take on the test results and offers some thoughts on what he expects to see when Jimmy returns.

Ketonix breath ketone meter
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“We know that total cholesterol is a poor marker for cardiovascular health. Many people that have heart attacks have low cholesterol.”

- Dr. Will Cole

“I think de-stressing, slowing down and getting more good amino acids with keto carnivore have helped spike my testosterone levels to double what it was.”

- Jimmy Moore
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Be sure to go back and listen through the archives of Keto Talk during the hiatus and enjoy the body of work we’ve put together. Six months will be over before you know it and we’ll be back with more great episodes of the show you love.

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Aug 22, 2019

Today on Keto Talk we have a special show for you as Jimmy gets ready to wind down for his six month sabbatical beginning on September 1. This past weekend Jimmy made his last personal appearance before going away and was joined by his co-host Dr. Will Cole for this very special LIVE edition of Keto Talk.

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“A good old fashioned elimination diet is one of the best ways to get to the bottom of food intolerance.”

- Dr. Will Cole

“Part of the challenge of all this is you don’t have an easy way to know what it is that you are supposed to eat. What we try to do on our show is clear away some of that confusion.”

- Jimmy Moore
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The Great Canadian Keto Conference was a major success with a day packed with information, fellowship, and fun. You won’t want to miss this event next year. Be sure to follow their website at

About the event:

As we all know, today’s current food culture is toxic and the ‘modern’ diet is now the leading risk factor for disease. Decades of food industry lobbying, deplorable ‘science’ and inaccurate food guidelines have made Canadians overweight, obese and sicker than ever.

This conference has been crafted with YOU in mind. Bringing you knowledge and awareness from experts you can rely on! Are you ready to be inspired, take charge of your life and focus on your Health, Wellness and Transformation? When you learn to make the right food choices, you say NO to disease and YES to a healthier and more sustainable lifestyle.

This year’s speakers included such keto leaders as:

  • Jimmy Moore
  • Christine Moore, NTP
  • Dr. Will Cole
  • Dr. Adam Nally
  • Amy Berger, MS, CNS
  • Dr. Ken Berry
  • Megan Ramos
  • Gillian Szollos
  • Joanna Wilcox
  • and more
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Aug 8, 2019

Today we have a very special episode of Keto Talk with The goopFellas. As most of you know, Jimmy’s weekly co-host Dr. Will Cole recently launched a podcast on Gwynyth Paltrow’s goop network with his co-host Chef Seamus Mullen. Together they tackle subjects on health and well being with a focus on transformation.

“I know from seeing patients how prevalent anxiety is in all types of people, but it’s important to talk about so that we can get tools to start feeling better and whole.”

- Dr. Will Cole
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On this special episode of goopFellas on Keto Talk, cohosts Dr. Will Cole and Seamus Mullen break down the ketogenic diet. Should you switch to a high-fat, low-carb baseline? What would you eat in a typical day? When do our bodies go into ketosis, and what are the potential health benefits? What about intermittent fasting? Seamus shares his personal experience of changing his diet while healing from rheumatoid arthritis. And Will shares examples from his functional medicine practice, the kinds of diets he typically prescribes for patients with chronic inflammatory and autoimmune conditions, and how he tweaks the conventional keto model to be cleaner and more vegetable-forward for anyone (he’s the author of Ketotarian, after all).

“The decision you make in your mid 30s definitely impact what happens to you in your 40s. The sooner you start to take care of yourself the better you will be.”

- Seamus Mullen
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goopFellas: What drives people to change, to heal, to reinvent themselves? Two friends who have become familiar with unlikely personal transformations talk with people who have experienced profound shifts in perspective and well-being: Chef Seamus Mullen himself almost died from rheumatoid arthritis, and functional medicine practitioner Will Cole’s day job is helping people uncover and overturn the roots of dis-ease. Together, they get at the catalysts that bring people out of their dark night and into their purpose.

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Aug 1, 2019

We’re back for another info-packed episode of Keto Talk! In this episode, Jimmy and Dr. Will Cole answer your questions about Overwhelming Carb Cravings On Keto, Deposits Of Cholesterol On Face, Genetic Liver Cirrhosis, Bloating On Keto, Diabetic Neuropathy Treatment, and more!

“It’s not the ketogenic diet that failed them, it’s how they prepared for it and what they were eating that was not working for them.”

Dr. Will Cole

People can so easily psyche themselves into doing keto badly and then blame keto for not working: Tried the Keto Diet, and I Hated Each Second of It

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  • Do people with Celiac disease need to eat more fat due to poor absorption?
  • Does keto lead to an elevated level of bilirubin in the urine?
  • Should I be concerned about my LP PLA2 being elevated (over 200) after starting keto?
  • Why is my fasting insulin so high at 7.3 despite being strict keto without cheating at all?
  • What if any impact does your blood type have on your body’s ability to be in ketosis?
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“I think the best ketogenic approach in the world will become unraveled if you aren’t sleeping and are stressed.”

Jimmy Moore

Your Questions:

What can I do to help get rid of the persistent and overwhelming carb cravings that hit me even while eating keto?

Hey Jimmy and Will, 

I recently joined in on Jimmy’s 7-day fasting challenge on Instagram and they were so incredibly helpful. I was really hoping that would be a reset for me and a springboard into eating clean keto. I’ve been struggling for years with on again off again low-carb eating, but I just have super intense carb cravings. I ended up going through my time of the month and struggling through that last day of the fast and then crashed and burned back into eating tons of carbage afterwards. I caught your emotional eating JIMMY RANTS episode and I just need some help with figuring out how to conquer the craving insanity that I just can’t always willpower through. I want to be successful once and for all, but I’m feeling like a failure here, yo-yoing at very high weights, with Type 2 diabetes. I know that the answer to this lies within eating a keto template and I’m not afraid to put in the hard work to make it happen. But I definitely feel controlled by food.  I refuse to believe that I have to have a dangerous weight loss surgery to conquer this problem, but I’ve been winning some battles but losing the war for years. What do you recommend for the obsessive, overwhelming cravings, and persistent thoughts about food? How do I get actual control over this?

Thanks so much,


If cholesterol isn’t a bad thing, then why did keto lead to these permanent deposits of cholesterol underneath my eyelids?

Hey Jimmy and Dr. Cole,

Thanks for this podcast. I started reading Jimmy’s book Cholesterol Clarity recently because I developed these yellow bumpy lines under my eyes and was told it’s because I have high cholesterol.  I went to the doctor and immediately they wanted to put me on statins. I hate going to the because of this kinda thing. They didn’t even go over the results with me. They had the front desk call me and tell me I had a high cholesterol number and that there was a prescription for statins waiting for me at the pharmacy.  I didn’t take them, of course, and I retested after a three-month, 30l-pound keto weight loss and it was even higher. The doctor again insisted I take a statin and I again refused. 

My question for you guys is if cholesterol isn’t bad, then why do these permanent deposits of cholesterol end up on my face? They look horrible and I’m told they will never go away on their own. How and why does this happen? I wanted to show you these yellow things on my face and I wondered if you had any knowledge about them. Thank you for answering my question.


Would a genetic liver cirrhosis condition be hindered or helped by eating a low-carb, high-fat, ketogenic diet?

Greetings Jimmy and Will,

My boyfriend was recently diagnosed with liver cirrhosis which developed as en effect of a genetic disorder he was not aware of. He’s never been much a drinker and he definitely doesn’t drink now. He works out regularly and eats somewhat “healthy” according to his doctors. He’s in great shape especially for someone with only 20% liver function. I read somewhere that a hepatic diet is made up of primarily carbs since protein breakdown is impaired and fat is bad for the liver. I by no means consider myself an expert on nutrition and metabolism, but this sounds like total BS to me. It doesn’t make sense to feed your liver carbs which turn into sugar. In my mind, it just makes sense that a keto diet is the way to go in conjunction with coffee enemas perhaps. What do you think? I want to learn and do as much as I can to help my boyfriend have the best life and the best health possible. 

Thank you,


Why do I have bloating when I eat keto foods? Why won’t my Ketonix breath ketone analyzer show the presence of ketosis with anything I do?

Hi Jimmy and Dr. Cole,

I love your show and never miss an episode because it really helps keep me on track. I’m a 31-year old breastfeeding female and have been eating keto since January 2017. When I transitioned to keto, I had already been breastfeeding my daughter for 10 months and I was starting to struggle with weight gain and hunger that was much worse than when I was pregnant. I ate whole organic foods and took probiotics for years but still consumed far too much sugar (honey, coconut sugar, and grains) and I knew I had to make a change when I started gaining more weight than I ever had in my life and having an insatiable appetite for sugar. 

My transition was rough and I had keto flu and lightheadedness for weeks despite consuming plenty of water, salt loading, and taking a multimineral supplement. Urine test strips at the time showed that my ketones were off the charts high. At the beginning of my pregnancy my hemoglobin A1C was prediabetic, but after a few months on keto it was down to normal. My fasting blood sugar in the morning is now 83, and it drops to 76 after my 25 minute beginner’s strength training workout and 59 two hours after my usual breakfast of scrambled eggs. In the evening, 2 hours after dinner, it is around 80. I lost about 30 pounds in the first months and my milk supply never dropped (I’m still breastfeeding now, almost a year on keto later, with no problems.) 

I love the ketogenic way of eating and am so thankful to be off carbs, but I have two main concerns: the first one is constant bloating. When I still ate carbs I had stomach pain every morning that improved after eating breakfast. Now that I’m keto I tend to feel very bloated after meals. I eat dairy and nuts, but temporarily cutting them out of my diet and it doesn’t seem to make a difference. Sometimes my worst bloating is after eating something like riced cauliflower with bacon. It seems like everything sits in my stomach too long. And I really can’t handle seltzer water! I once had a UGI endoscopy in my stomach for the stomach pain years ago and it showed everything normal except for low stomach acid. Could that be the problem? How do I increase stomach acid? I also sometimes have nausea and an acid taste, like reflux symptoms, although I’ve never had heartburn. 

My other concern is with testing my ketones. I use the Ketonix breath analyzer and no matter what I do, I blow green. If I have a glass of dry champagne the night before and keto treats full of almond flour and cheese, I blow green the next day. If I intermittent fast for three days and eat very strict keto, I still blow green! How is this possible? Am I truly in ketosis? Thank you so much for your help!



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Would the inevitable diabetic neuropathy be rectified more effectively with IF and keto than with Gabapentin?

Hey guys,

My boyfriend’s mother was just diagnosed with Type 2 diabetes. Unfortunately, she suffers from horrible neuropathy and finds it very difficult to sleep at night which is very common. I have read on the Internet that people with neuropathy most of the time are prescribed a drug called Gabapentin. To my surprise, they are also prescribes to patients as antidepressants. The more I think about it, long-term use of these drugs has to be very difficult on the kidneys and liver which is a double whammy for diabetics who already have issues with both of these organs.

To me, it seems intermittent fasting and keto can help solve this neuropathy without the need for any risky medications. In your functional medicine practice, Dr. Cole, have you found this to be true in your patients?


Jul 25, 2019

We’re back for another info-packed episode of Keto Talk! In this episode, Jimmy and Dr. Will Cole answer your questions about Edema After Starting Keto, Upper Respiratory Infection, Pituitary Microadenoma, Swollen Ankles On Keto, Increased Blood Pressure And Racing Heart Eating Very Low-Carb , and more!

“Saturated fats can handle a higher temperature as a general rule, and the benefits far outweigh the concerns.”

 - Dr. Will Cole

Will and Jimmy are featured speakers at the August 17, 2019 Toronto conference called Great Canadian Keto.


  • Is it possible to be making therapeutic blood ketone levels, but still experience higher blood sugar levels at the same time?
  • Are you concerned about increased cancer risk because of heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) in meat?
  • How should I handle eating keto when I work the night shift half the week and daytime the other half of the week?
  • If heating fats make them more carcinogenic, then why would you ever consume cooked fats from even bone broth?
  • How can someone without a gallbladder who has also had gastric bypass surgery do a ketogenic diet?
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“Folks think that you can’t eat keto after having their gallbladder removed. Christine had hers removed in 2006 and she eats more fat than I do.”

Jimmy Moore


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Your Questions:

– Why did I develop edema in my lower extremities after I started eating a low-carb, high-fat, ketogenic diet?

Hey Jimmy and Will,

I am a natural bodybuilder and have been for over 40 years now. For the past decade, I’ve consume a 100% grass-fed and non-GMO organic diet. In fact I was Paleo before I even knew what that was. In 2017 I started on keto and it was an easy move over from Paleo. I got into a state of nutritional ketosis very quickly with blood sugar in the 80’s and blood ketones between 1-2. My blood pressure improved to 110/75 and fasting insulin down to 3.8. I felt great and had no medical issues whatsoever.

But then I noticed something pop up out of nowhere last year where I developed edema in my calves, ankles, and feet. I tried upping my magnesium, drinking more water, taking in substantially more sodium, moderating my protein, and doing an 18/6 intermittent fasting schedule. None of it has worked. I weigh 150 pounds have have 9% body fat. Do you have any further suggestions I can do to help with this? What is it about going keto that perhaps let to this condition?

Warmest regards, 


– Why have I developed several upper respiratory infections ever since I started keto when I’ve never been sick like this in my life?

Hi Jimmy and Will.

Thank you for what you guys do for everyone in the keto community. I only just found this podcast this year and have binged listened to almost all of them. I am a registered nurse and have taking care of the sickest of the sick in the city of Pittsburgh. I now work normal M-F hours with low stress.  I’m on Synthroid for Hashimoto’s hypothyroidism, but my immune system has been so stellar I’ve hardly ever gotten sick. But ever since starting on keto, I’ve had three upper respiratory infections eating this way. While I’ve lost 20 pounds, have great brain health, increased my energy, and spontaneously intermittent fast for 16 hours at a time while stabilizing my blood sugar and increasing my blood ketone levels, these respiratory issues are discouraging and throwing me for a loop. I’m assuming it’s a gut health thing that needs to be healed from years of neglect before starting keto. How do I provide a boost to my immune health to prevent another infection from developing? 

Thanks for your help,


– How do I manage my cravings to consume way too many calories on keto because of my pituitary microadenoma condition?

Hi Jimmy and Dr. Cole, 

I’ve been on a weight loss journey for about a year, and went keto 6 months ago. Before keto, I lost over 15 pounds, then switched to keto to optimize my athletic performance and brain function while continuing to lose weight. I also wanted to try to heal my hormones with a low-carb, high-fat diet. I have a pituitary microadenoma which is essentially a small tumor on my pituitary gland that secretes high levels of prolactin. These high levels of prolactin suppress estrogen production. In short, it means I have high prolactin, low estrogen, and have not had a period in 2 years which ultimately is leading to infertility. 

I am wondering if this hormone imbalance could be suppressing my weight loss and/or increasing my hunger and questioning whether keto would be a useful tool to balance my hormones. I haven’t lost any weight since beginning on keto and I still struggle with food addiction/binge eating. Unlike what other people report eating a ketogenic diet, I don’t really get full or reach satiety until I’ve consumed way too many calories. I know calories aren’t what they’ve been made out to be, but they do have to count because they’ll get stored as body fat if consumed in excess, right? Got any tips for me?

Thanks guys and keto on!

Kayla from Canada

– What can I do about the swelling in my ankles and lower legs that started happening after I went keto?

Hi guys, 

I love your podcast! I’ve been keto for over a month and have been testing for blood ketones. I’m doing well but I have been retaining water in my ankles and lower legs. I get leg/shin cramps at night so I have been adding a magnesium/potassium supplement to help. They have eased up quite a bit but the swelling has increased. Ketones are still strong, but my weight loss stalled out after losing eight pounds. I had a total hysterectomy at 35 years old with no hormone replacement therapy and I’m 56 now. Any suggestions on what to try next? 

Thank you for your help,

FBomb Fat Bombs
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– Why does my blood pressure and heart rate shoot way up when I am eating very low-carb keto and engaging in periods of fasting?

Hey Jimmy and Dr. Cole,

I’m listening to an older episode where a woman had asked about cortisol and low-carb. I haven’t taken a test for it yet, but when I fast, long-term or intermittent, and consume a very low-carb diet (under 20), my blood pressure shoots through the roof and I get major heart palpitations. When this happens, I purposely knock myself out of ketosis and my heart rate and blood pressure normalize again. I’ve been keto for four months and I’m not really losing any weight yet. I’ve felt pretty good eating this way, but I have noticed being a bit more tired than normal at times. I take all the recommended electrolyte supplements and plenty of water and salt. So what am I doing wrong?

Thank you,

Jul 18, 2019

After being gone for several weeks as Jimmy and Will have dealt with the busyness that comes with summer, we’re back for a couple of months before Jimmy heads off for his much deserved six-month sabbatical (more on this coming up). In this episode of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Keto For Type 1.5 Diabetes, Myasthenia Gravis, Keto For Cancer Support, Period Carb Cravings, Female Balancing Testosterone While Keto, and more!
“It’s not always the goal to produce higher and higher ketones, you should be at a therapeutic level for you.”

Dr. Will Cole
Why do we have to be “at war” over our food choices? 
Welcome to the 2020 diet wars


Why do I have pain in my kidneys when I am in the midst of doing intermittent fasting?
Why are my blood ketones low when I am intermittent fasting, but then go higher when I eat dietary fat?
Are there any concerns about having much higher blood ketone levels in the 5-8 range while extended fasting?
Is it worse on the body to do a 2000-calorie OMAD vs. spreading out the food over a couple of meals in a feeding window?
Why do I get major diarrhea whenever I take any dosage level of magnesium in supplement form?
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“My goal would to have a blood ketone level of zero, but all the benefits of nutritional ketosis. I want to use up all of the ketones I make.”

Jimmy Moore

PBFA and Upton’s Naturals challenge Mississippi law restricting plant-based and cell-cultured ‘meat’ labeling
Carbs: How low can we go?
Comparisons to Soda Reveal Unexpected Consequences of Drinking Fruit Juice
A cancer researcher who’s been keto for 6 years thinks our modern diets are an ‘axis of illness’ — here’s what he eats instead
Pompe disease
STUDY: Low-carb diets like keto ‘reduce diabetes and stroke risk even without weight loss’
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Your Questions:

– Is engaging in fasting or a low-carb/keto diet a prudent nutritional strategy for someone with Type 1.5 diabetes?

Hey guys,

My question is about my mom who is in her 60s and was diagnosed with Type 2 diabetes a few years ago. Her diabetic nurse jokes she is a Type 1.5 because her pancreas is not producing much insulin. She eats a low-carb diet but still has trouble controlling her blood sugar. It’s not out of control but higher than ideal. She says there doesn’t seem to be any discernible pattern to it. 

Her diabetic nurse has her on a consistent low dose of insulin daily. At her last check-up she was spilling a little protein into her urine. I encourage her to try eating less veggies to lower carb count because she eats tons of them. But she does eat lots of eggs, cheese, and nuts. I think those are her main staples apart from the veggies. She eats healthy fats but maybe not enough of them and some berries as well. 

I know she’s not a big fan of eating meat—no pork or chicken. She used to drink a glass of wine at night but I think she’s cut back on that. She tried fasting but it didn’t agree with her. I’m now wondering if she’s fat-adapted. She says sometimes she is lightheaded in the morning which makes me think her blood sugar or blood pressure is low at that time. Or maybe she needs more electrolytes like salt. I’m wondering if because her pancreas doesn’t work well whether fasting or low-carb/keto are still a good treatment protocol. 

Any advice you can give would be greatly appreciated as she gets frustrated and scared and I don’t know what else to suggest. Thanks for taking the time to read this!


– Will eating a ketogenic diet cause the condition Myasthenia Gravis to become worse?

Hey Keto Talk dudes,

My ears perked up when I heard Jimmy mention that his mom suffers with Myasthenia Gravis (MG) in a recent episode. I have been searching for MG and keto information, but there doesn’t seem to be much connection with them. I had been low-carb off and on for years, but this past January decided to try a more strict keto plan to “clean up” after an indulgent holiday season. Within a week I woke up with an odd drooping eyelid and a few days later started suffering from intermittent but terrible double vision. After several visits to the eye doctor and a neuroopthalmologist that included an expensive MRI and inconclusive blood tests plus other weird symptoms of intermittent but profound weakness in my legs and neck, he thought I had MG. Of course, he blamed keto for bringing it on. But now he’s got me wondering if keto is doing more harm than good with this condition. I’m willing to take any supplements or do other strategies to help with this so I can stay on my keto diet.

Thanks for helping me with this,


– Where can you turn to find quality information and professional support for treating cancer with a ketogenic approach?

Hey Jimmy and Dr. Cole,

I have been doing a ketogenic/LCHF diet for three years on my own after reading Keto Clarity and listening to your podcast. Now my mother has been diagnosed with lung cancer and her functional medicine doctor is encouraging her to begin keto. I know there is a difference between what I am doing and what is necessary for therapeutic levels of ketosis for something like cancer. My question is where can we find information on or get guidance from someone who can guide her through starting this diet correctly? Every cancer center has dieticians available, but none of them know anything about keto or fasting or anything remotely useful other than “drink Ensure” “don’t lose weight” “eat plenty of calories” etc. Where do you find someone with real knowledge?

– How can I control the major carb cravings that overcome me during my time of the month?

Hi Jimmy and Will, 

I started listening to your podcast in the Fall and began seeing a Naturopath which has changed my life! I was diagnosed with hypothyroidism and started taking supplements to balance my hormones and heavy painful periods. I began taking desiccated thyroid about a month ago and it has made a huge difference to my energy and mood levels. I have not eaten sugar in over 6 weeks which I have found to be very helpful in balancing my hormones and moods. My periods are not as heavy but still very heavy and I struggle with major carbohydrate cravings right before my period starts. I usually end up caving in and eating pizza or something very carby then feeling terrible the next day. Any helpful suggestions for managing this? Do I need to up my fat or protein intake around this time of the month? 

Thank you very much, 



– How can I effectively balance my testosterone levels as a woman without resorting to a hysterectomy or oral contraceptives?

Hi Jimmy & Will,

I could use some ideas from you about balancing testosterone. I am 36 years old, have been keto for almost a year, and dropped 35 pounds effortlessly. I have PCOS and stopped taking oral contraceptives after 20 years of use. I cannot tell you how much better I feel off of them. However, my testosterone levels are now quite high. I have used the at home Everlywell hormone testing and it measured at 159ng/dl (normal 16-55). The hair on top of my head is very thin, my cycles are unpredictable with a lot of mid-cycle spotting, and I have painful large zits on my face, neck, and chest. I found an article on PubMed referencing licorice root as an aid to lower testosterone in women. So I started taking a conservative dose to start (1g, recommended was 3.5g). What else can I do to help this? When I went to my OBGYN with my concerns, his options were to have a total hysterectomy so I don’t have to deal with periods, get back on oral contraceptives, or an IUD. The only lab work he wanted to run was a CBC to make sure I wasn’t anemic from all the bleeding. 

I have made so much progress with keto so far eliminating pain from the cysts and getting my blood sugar and weight under control that I refuse to believe I have to take hormones to make this better. The only other lab markers that were off was my end of day cortisol at 3.4ng/ml (n=0.4-1.0), and my progesterone:estradiol ratio at 49 (n=100-500). My estrogen was previously low so I started supplementing with a phytoestrogen. I think stopping that will bring this ratio back down. I am reluctant to spend my time going to another MD if those are my options.




Jul 11, 2019

We’ve been gone for several weeks as Jimmy and Will have dealt with the busyness that comes with summer, but we’re back for a couple of months before Jimmy heads off for his much deserved six-month sabbatical (more on this coming up). In this episode of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Therapeutic vs. Fat Loss Ketosis, Impact Of Dietary Fat On Reflux, Trigeminal & Occipital Neuralgia Migraines, Ankle Swelling, and more!

FBomb Fat Bombs
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“Sometimes even in the context of the Keto Diet, you need to address other problems like binge eating.”

— Dr. Will Cole

 Where have Jimmy and Will been the past two months?

  • Jimmy’s experience and insights slowing down heading into his 6-month sabbatical
  • Will’s successful new podcast goopfellas and the new opportunities that have come his way


  • Why do I still want to binge eat even eating low-carb, ketogenic foods?
  • What’s the deal with dietary fat intake when you first start keto vs. when you become fat-adapted? 
  • Why does my menopause keep making me want to go back to eating carbs again?
  • What impact do essential oils have on blood ketone levels? Mine go way up when I use them!
  • Are the at-home A1c testing kits (like A1c Now) accurate or should it be tested at your doctor’s office?
Keto Chow
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“I’ve noticed that just the act of slowing down has caused me to think about things I haven’t had time to think about and it’s spilling out.”

— Jimmy Moore


Your Questions:

– Is it possible to be in a therapeutic level of ketosis that isn’t ideal for producing adequate fat loss?

Hey guys,

I have been doing keto religiously for the last six weeks and I already love it! I lost eight pounds pretty quickly and then it slowed down dramatically ever since. I started testing my blood ketones and had a 2.5 reading in the morning. When I calculated my glucose/ketone index, it was 1.67 and I’m concerned that I have reached a therapeutic level of ketosis that’s not conducive necessarily for weight loss. How do I get the fat-burning benefits of ketosis to kick in so I can get off this plateau? I am in a caloric deficit right now eating 1300 calories with my macros being 12g total carbs, 130g fat, and 82g protein.  I try to reach a gallon of water a day, I sleep 7-8 hours a night, and my stress levels are good. I also workout 5-6 days a week, do 3 days of heavy lifting a week, and two days of HIIT training. Overall, I feel great in terms of my energy and strength. What do you think is going on with me?

I really appreciate any and all help you can provide,


– Is the high-fat aspect of keto making the symptoms of LPR worse? What can someone with this do?

Hi Jimmy and Will, 

Ever since going keto I’ve developed a case of laryngopharyngeal reflux (LPR)—no real heartburn, just throat burning, trouble breathing, coughing, ear ache, stuffy nose, etc. I’m convinced all these symptoms are a result of the high-fat intake on my ketogenic diet. A number of people online have been reporting similar symptoms after starting on nutritional ketosis and seeing it resolve after going off of it. I’ve even seen my dad who had this same condition and doesn’t eat keto have problems, too, because of the fat he eats in his diet. So what do I do? I’ve tried using digestive enzymes, eating smaller meals, reducing my fat as much as possible while still trying to maintain ketosis, but nothing seems to work. I’ve been tested for H. Pylori twice, but both times it came back negative. I’m using keto specifically for my mental health, so I really don’t want to give it up since I’m getting those benefits. I’m at a loss about what to do. Can you help?

Many thanks, 


– Will a ketogenic diet give me relief from my constant migraines due to trigeminal/occipital neuralgia?

Hi Jimmy and Dr. Cole,

I recently discovered the Keto Talk podcast in January and I’m really loving it so far. I have been experimenting with a keto diet for managing trigeminal/occipital neuralgia that gives me nearly constant migraines all the time. I had nerve decompression surgery last year and while it has helped, it’s still not as much as we’d hoped it would be. I’m hearing a lot of people in the migraine community say they have eliminated their migraines completely with keto nutrition. My doctor are completely skeptical about that and they keep saying I’ll see little to no effect from changing my diet. The ironic part is the daily medicines that I am taking to manage this—Lyrica, Vimpat, Metroprolol and the emergency pain medicines Trammadol, OxyContin, and a clonidine tablet for high blood pressure negatively impacts my metabolism enough that it makes someone like me trying to get into ketosis that much harder. What do you think about this and how I should proceed?

Thank you for all you do, I appreciate your show and I have learned so much listening. I’m working my way through older podcasts as well as the current ones.


– What do I need to tweak in my ketogenic diet to keep my ankles from swelling up in warmer weather?

Hi Jimmy and Will,

I’ve been keto for 10 months with blood ketones ranging from 0.4-2.1 and my A1c is very healthy at 5.0.  I’ve learned so much from your show and was hoping you could offer advice on how a ketogenic diet and/or certain supplements could help me control swelling in my ankles that tends to happen when the weather warms up.  I’m 53 years old and have lost about 30 pounds since starting keto. Three different doctors have all told me that need to be wearing compression socks or taking water pills to help with this. I was really hoping that keto would help with this problem,  but with the warmer weather my left ankle is swelling up.  I walk 3 miles a day for exercise but also sit a lot for my work.  The swelling generally goes away overnight, but returns the next time I have to sit a lot for work or when I travel.  I drink plenty of water and supplement with 400-600mg of  magnesium oxide and pink Himalayan sea salt everyday.  Is there anything else I can do to help control this swelling?

Thank you so much for any advice you can offer!



– How can eating a ketogenic diet help me with the loud tinnitus I’m experiencing from Meniere’s disease?

Hi Jimmy and Dr Cole,

I love you two SO SO much! I never miss an episode. Dr Cole worked with my mother and completely changed her life! My question for you guys is about Meniere’s disease and keto. I was recently diagnosed with this and I have had tinnitus ever since I can remember. Two and a half months ago, the ringing suddenly got really loud nearly overpowering all the other noises surrounding me. Needless to say, my sleep quality dropped and after seeing an ENT, Chiropractor, Audiologist, an Acupuncturist, and even an Atlas Orthogonal, I am spiraling out of control, exhausted, and not knowing where to turn. My general practitioner told me I had to change my diet from keto to eating more FRUITS, VEGETABLES, and WHOLE GRAINS. He also said I had to lower my salt significantly. Honestly I would do anything at this point to make it go away, but I can’t with good conscious and two other autoimmune diseases (Interstitial Cystitis and Reynauds) switch to a high-carb, low salt diet. I tried to explain to my doctor that on keto that it was necessary for electrolytes. What do you guys think about this? 

Thank you for your help,


Apr 25, 2019

In Episode 147 of Keto Talk, Jimmy and Dr. Will Cole do a deep dive on the subject of offal and why it is so important to eat 'nose to tail'.

“Especially for people following the carnivore protocol, this is great because offal is one of nature's multi vitamins.” – Dr. Will Cole

“When you think back to our hunter gatherer ancestors when they got an animal they didn't let any part of it go to waste.” – Jimmy Moore

Offal and organ meats are most popular when used from beef, pork, lamb, or poultry. The different kinds of organ meats that you can eat include:

  • Brain
  • Heart
  • Liver
  • Kidney
  • Tongue
  • Gizzard
  • Sweetbread

History Of Organ Meats

Each culture has their own opinion of organ meat and each views it slightly different than the next. In some cultures, organs are consumed daily while in others certain organs are illegal to eat. One thing that stands true for all cultures is that organ consumption has changed over the years.Centuries ago, not only were organ meats just eaten, they were praised and loved. When food was hunted and gathered there was a lot of effort put into supplying it for families and tribes. Hunters didn’t just walk to the local supermarket to buy meat, they had to fight for it. And when you’re putting that much effort into hunting food for your family, you use every ounce of it that you can. Not only was it eaten just so it wouldn’t go to waste, the organ meat was reserved for the respected society members. Whether it was the political kings and leaders, the hunters, or the elders; the organ meats were regarded as the best and saved for the best.

Over the years it has changed to be eaten by all, not just the well respected, in almost all countries. In some countries, organ meats are served as common street food and others as appetizers and entrees in expensive restaurants. No matter how common throughout the world though, eating organ meat isn’t a widely loved meat here in the United States, yet.

Why People Avoid It

I will admit that the taste can take some getting used to, but they provide far too many benefits to avoid it. Another reason that organ meats invoke negative perceptions is the thought of toxins. The misconception in our society is that the animals’ toxins are stored in their organs; and when eaten, the toxins now move into our bodies. This would make sense, however the toxins are not actually stored in an animal’s organs. The organs, the liver in particular, are where the toxins move to get filtered out. Once there, the liver doesn’t store it, but rather decide where it should be moved to. Most times, the liver moves any toxins to the kidneys where it is then expelled through urine. The toxins are removed from the animal’s organs and bodies before it has the chance to enter our bodies.


The benefits of eating organ meat reach far and wide. Each one acts as a superfood that provides many more nutrients to our bodies than the animal muscle meat that we normally eat.

1. CoQ10

One of the main nutrients that organ meats offer is the Coenzyme Q10, otherwise known as CoQ10. This coenzyme is found in the largest amounts in animal hearts. Like all coenzymes, our bodies naturally produce this nutrient, but only in small amounts and not enough that we need. That’s where organ meat comes in.

CoQ10 is also designed to help other enzymes digest and break down food. When it comes to energy, it isn’t always the same and instead comes in many different forms. The form that our cells use is called adenosine triphosphate, or ATP. But when our energy comes in the form of fat or carbohydrates that we eat, how does our body make that change to supply energy to our cells? CoQ10 is crucial for the body to begin and sustain the ATP synthesis process to continually supply our cells with energy each day.

Our brain and cardiovascular systems are also impacted by this coenzyme due to its antioxidant features and its effect on oxidative stress. Although further research is needed, it is recommended to people with or at risk for cardiovascular disease to up their CoQ10 intake along with regular medications. Eating foods high in CoQ10 helps fight the backlash that come with these prescribed medications and keep blood flowing.

When it comes to our brain, it has been shown that those with cognitive disorders have lower levels of CoQ10 that contribute to the issue. As potential agents are looked for to combat the cognitive decline we see on a daily basis, research suggests that CoQ10 has potential to be used medically to fight the decline.

2. Vitamin A

Organ meats also offer one of the largest amounts of the antioxidant Vitamin A. When taken in supplement form Vitamin A in mass amounts can result in toxicity; but, Vitamin A present in food does not lead to any toxic results even in large amounts. When the body breaks down nutrients from food sources it can access how much our individual bodies need and expel any extra, avoiding any issues.

There are two types of Vitamin A: retinol, or active Vitamin A, and beta-carotene. Active Vitamin A is present in organ meats and other animal meat in smaller quantities. This type can be broken down and used by the body right away, making it a perfect source to get this nutrient from. Beta-carotene, found in many vegetables, cannot be used by the body unless broken down and changed. Even though vegetables are great for you, they are an inefficient source of Vitamin A because of the work and stress it has on our bodies just to use it.

Vitamin A can also do a lot of good when it comes to the immune system. In a recent study of children under 5 in Colombia, they came to the conclusion that increasing the childrens’ Vitamin A intake was the most effective way to protect against disease. Not only was it the most effective, it was also the least expensive way to protect the immune system in the children to ensure health. When Vitamin A is present, the mucosal barriers that become damaged by infection can regenerate and repair themselves to provide immune protection. If your body is lacking this immune-boosting vitamin, then regeneration does not occur and infections become more prevalent and can spread faster.

One of the most noticeable benefits of Vitamin A is the glowing and clear skin it can lead to. Its support of cell regeneration keeps wrinkles away while the anti-inflammatory properties protect against acne and skin irritations.

3. B Vitamins

Organ meats also supply us with important B Vitamins. All of the B Vitamins that are present in organ meats offer some kind of help to our cardiovascular systems. These vitamins can maintain healthy levels of cholesterol, blood pressure, blood triglycerides, and homocysteine. When all of these are at healthy levels, the risk of developing a heart or cardiovascular issue is greatly diminished.

Vitamin B7, also referred to as biotin, is known for its ability to enhance beauty through the positive effects it has on hair, skin, and nails. One thing needed for radiant skin is fatty acid synthesis, and, of course, biotin aids this process and can therefore fight the effects of aging and prevent wrinkles.

Biotin deficiency and thyroid problems can both lead to thinning hair and hair loss. This can be reversed and restored through incorporating more biotin into your diet. The same is true for restoring weak and thinning nails back to full health. For this reason many beauty products and beauty enhancing supplements can be found with biotin. However, biotin is not as effective when use topically compared to when it is when ingested. 3 ounces of beef liver provides 30 mg of biotin, which is the daily recommendation for adults.

The B Vitamins in organ meats also aid in hormonal health and pregnancies. Folate, otherwise known as B9, is one of the most needed vitamins for mothers and babies for a healthy pregnancy. Folate supplements are often recommended by doctors, but I truly believe that when available, food medicines are the best way to get your daily dose of vitamins. Vitamin B6 can also decrease the risk of erectile dysfunction, reduce nausea related to pregnancy, and calm menstrual cycle cramps.

Vitamin A for immune system calming.

Vitamin A is essential for a strong immune system, and vitamin A deficiency has been linked to autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. Researchers suspect the reason has to do with our dendritic cells, which send out a “red alert” at the sign of a supposed invader, to stimulate immunity, or a “calm down” message that tones down excessive and damaging immune reactivity. The “calm down” message makes use of vitamin A!

Vitamin K2 for brain and spinal cord healing.

One study in the Journal of Neuroimmunology found that vitamin K2 was effective at inhibiting the pro-inflammatory iNOS in the spinal cord and the brain immune system in rats that had multiple sclerosis symptoms. That suggests it could do the same for humans, but unfortunately, K2 is one of the most common nutrient deficiencies in the western diet. You can fix that with the right food medicines!

Iron to replenish deficits.

Iron deficiency anemia (IDA) is linked to many autoimmune diseases, but it isn’t clear how much of this is cause and how much is effect. One likely reason is that ferritin (stored iron) is mostly absorbed in the intestines. When absorption is compromised by inflammation and autoimmunity, iron stores can fall too low, and as you may already know, damage to the gut lining and leaky gut syndrome are considered (in functional medicine) to be preconditions for autoimmunity.

Micronutrients to quell inflammation and promote optimal function.

Micronutrient deficiencies – especially of selenium, magnesium, and zinc – are associated with several autoimmune diseases. That’s likely primarily due to chronic inflammation, which decreases the absorption of these vital nutrients. Yet, these micronutrients are required for the healthy production and conversion of the thyroid hormone, and thyroid problems such as Hashimoto’s disease are some of the most common autoimmune conditions. Supplementing with these micronutrients can help get thyroid issues back on track as you work on healing the gut and decreasing inflammation to increase micronutrient absorption.

Apr 18, 2019

In Episode 146 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Healing Chronic Fatigue, Elevated Glucose Response To High-Carb Meal While Keto, APAO2 Gene, Keto & A-Fib, Daily Laxative For Opiate-Induced Constipation, and more!


  • Will's exciting new podcast The goop Fellas Podcast
  • Why is being proactive about your health by doing things outside of conventional wisdom considered strange?
  •  How do you mitigate the effects of cortisol and insulin resistance (even while eating keto) induced by taking prednisone for Crohn’s disease?
  • What role could a ketogenic nutritional health plan play in the recovery from opioid addiction?
  • What’s the difference between saturated, monounsaturated, and polyunsaturated fats and how much of each do you need in your keto diet?
  • Should a Type 1 diabetic who eats keto and sees a major glucose rise from a powerlifting workout be concerned about the rise in glucose?
  • How do I eat low FODMAP real food-based keto to control my IBS when my doctor tells me the fat-digesting bile is flowing back into my stomach?

“At one point when I was on Lipitor before starting the Atkins diet I got my cholesterol down to 120, but you can ask my wife, I was NOT a happy man.” – Jimmy Moore

“With the rise in awareness in wellness you also have a rise in skeptics and trolls. You can be objective without cynical and name calling.” – Dr. Will Cole


– How do you heal fibromyalgia and chronic fatigue when you’re doing everything perfect in your ketogenic lifestyle?

Hi guys,

I’m a longtime listener listener and appreciate all of the information you give so generously! I’m trying to figure out how to heal from fibromyalgia and chronic fatigue syndrome which I was diagnosed with in 2014. I have eaten an LCHF diet for many years and lost around 30kg (~66 pounds). I'm 59 years old and have been a yo-yo dieter my entire life. On low-carb, I have been much more successful in stabilizing my weight and the trend has been moving slowly in the right direction with about 22 pounds left to go. It’s such a struggle. Even still, my fasting blood glucose is 5-6 mmol/L and blood ketones are 0.5-0.9 mmol/L.

I’ve been very strict in my keto diet for a while, but the aches and pain in my arms and legs from my fibromyalgia and chronic fatigue persists. The good news is my brain is a lot clearer and I’m able work again. It’s so difficult to find any doctors here in Sweden willing to run the tests I need to dig a little deeper into this. What would you suggest I do to help with my health issues? Thanks for your input.

Susan from Sweden

– Why is the blood glucose response to a higher-carb meal greater since I’ve gone strict keto than it was when I was only eating low-carb?

Hey Jimmy and Will,

Can you explain more about the blood glucose rebound effect that happens after eating keto for a while and then having a higher carb meal? I’ve noticed much higher blood sugar readings when I eat carbohydrates while on a ketogenic diet than I did just eating low-carb. I suppose it’s sign that my insulin resistance has gotten worse, but I can’t imagine why since I’m on keto. Granted, it is not always perfect in my keto diet and I don't track macros anymore. But my normal readings two hours postprandial might have been 130 before but now it’s 160.

Good luck with your six-month sabbatical, Jimmy. And thank you for answering my question.


– How can I optimize my keto lifestyle with the APAO2 gene mutation that makes it difficult to process saturated fat?

Hi Jimmy and Dr. Cole,

I have been keto for a year and a half and I’ve lost 60 without taking any medications. I recently learned that I have the APAO2 gene mutation that makes it difficult for my body to process saturated fat. My doctor insists that I cut my fat intake and eat a lot of vegetables. My LDL-P is 2418 and my heart calcium score came in very high at 268. I also have high oxidized LDL. I’ve been dairy-free for a year which has helped me boost my HDL cholesterol to an all-time high of 49. I took statin medications for almost 18 years before the side effects became too much for me to bear. I’m 68 years and just want to be as optimally healthy as I can possibly be. The one bright spot is my inflammation marker hsCRP is stellar at 0.3.

Should I be eating more lean proteins and increasing my intake of avocado, olives, and nuts along with eating more leafy greens?  I am considering the Ketotarian way of eating since it seems to fit my genetic needs at this time. I just hate to give up so many of the animal-based foods I enjoy.

Thanks for your help,



– Will a ketogenic diet help patients dealing with atrial fibrillation?

Hi Jimmy and Will,

I just listened to your special episode with guest cohost Dr. Jay Wiles from a few weeks back where you discussed the bogus a-fib study. As someone who has this condition, I appreciated your input on that. But you guys didn’t say whether keto would help with this disease or not.

My experience has been that my heart palpitations get worse eating keto and that if I backed off my thyroid medication I get relief from this. I’m not sure why, but I suspect it is the hormone regulatory effects that come from a ketogenic diet. Unfortunately, when I did this my TSH shot way up to (yes, that’s not a typo—338!), and my doctor was obviously VERY concerned. I went back on the medication for fear of not knowing what impact chronically high TSH would have on the body. (I live in Canada and doctors rarely test any of the other numbers on the thyroid panel).

Can you talk more about what impact eating keto has on patients with a-fib? Thanks so much.



– Is using senna leaf as a daily laxative to deal with opiate-induced constipation causing damage to the microbiome and general gut health?

Hey guys,

I eat >keto, but have a really bad case of opiate-induced constipation which forces me to use senna leaf as a laxative on a daily basis.  I try to boost my gut health with fermented foods, probiotics, and digestive aids. But it seems I’m hopelessly addicted to taking laxatives since I can’t poop without help. This is probably a silly question, but is my microbiome suffering from this? I haven’t had a solid stool in months. So embarrassing!

Thanks for helping me with this!


Apr 11, 2019

In Episode 145 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Persistent Itchiness, Bladder Pain While Eating Keto, Primary Hyperparathyroidism, Being Ravenously Hungry When Cutting Protein, Meal Timing To Increase Carbohydrate Intake, and more!


  • Will taking daily Holy Communion impact insulin levels and my ability to burn fat and ketones?
  • Is it normal to experience intense heartburn after breaking an extended fast?
  • Other than meditate or quit my job, how do I deal with the stress-induced panic attacks and weight gain despite eating keto?
  • I’ve heard keto and dry fasting can help me with my tinnitus. Is there any scientific evidence supporting this?
  • Why would my blood glucose remain elevated even after a 72-hour fast?

“You have to decide what is more important to you; the stress of a certain job or your health.” – Jimmy Moore

“It doesn't have to be carnivore or vegan. Find what makes you feel the best. We lack a sense of nuance in our current culture.” – Dr. Will Cole


Jimmy and Will answer your questions:

– Why do I have a persistent itch ever since I started eating keto? What else can I try to try to deal with this?

Hey Jimmy and Will,

I have dealt with an extremely annoying itch all across my back, shoulders, and inside my arms ever since I started eating a ketogenic diet. I’ve tried eating no dairy, but the itching persists. I stopped taking as much of my vitamin C, but that didn’t solve the problem either. I highly suspect this is coming from oxalate dumping in my body as I eat lots of almond butter, almond milk, and raspberries as a keto dieter over the past seven months. I used to be vegan and added back in red meat after years of not eating it to help with my kidney health. Any suggestions about how to deal with this annoying itch?

Thanks for listening,


– Why would I experience cramping, bladder pain, and diarrhea when I eat a ketogenic diet?

Hey Jimmy and Dr. Cole,

I was eating a keto diet and loving along with my husband, but I started developing some cramping pain in my bladder and diarrhea as well as feeling an urgency and a burning sensation when I went to the bathroom. I went to see my doctor who gave me antibiotics and I saw only marginal improvement so we switched medications. This song and dance went on for about a month or so, but I decided to go off of keto to see if that would help. I slowly started feeling better from the bladder pain, but I sure miss the benefits I was getting from it. What could be causing this in my ketogenic eating plan?

Thank you for your wisdom and help.


– What impact is my Primary Hyperparathyroidism having on my elevated blood pressure and weight loss challenges while eating keto?

Hey guys,

I’m a 63-year old woman diagnosed with Primary Hyperparathyroidism one year ago. I have doing strict keto for the past six months with a few slip-ups during the holidays. I have lost 40 pounds and about 20 inches off my body with another 25 pounds of weight loss to go. The pain related to this disease has eased up since I started eating low-carb, high-fat, but blood pressure has still remained elevated requiring me to take medication. How is this disease impacting the blood pressure and my ability to shed the rest of the weight off my body?

A thankful Ketonian,


3. Why did I get ravenously hungry when I reduced my protein intake and raised my dietary fat consumption?

Hey Jimmy and Will,

I hear you guys talk about moderating protein and eating a higher percentage of fat in the diet to be keto. I’ve been eating this way for about a year and have lost a total of 95 pounds and getting stronger each day. I’ve been consuming around 130g protein daily and stalled out in my weight loss efforts at 220 pounds. I dropped my protein down to 90g and raised my fat to 285g attempting to eat this in an 8-hour feeding window (16 hours of intermittent fasting). It went well for a couple of days and helped me break my stall. But then out of nowhere I started having ravenous hunger like I haven’t experienced before being in a state of ketosis. I workout six days a week, so I’m very active. Do I need to raise my protein back up again to help produce satiety with my keto meals? Any help or advice you can give is appreciated.



– Could spacing out your meals allow for more wiggle room for a keto dieter to consume more carbohydrates than 50g in a day and stay ketogenic?

Hi guys,

I have been keto for many years and am curious about the role of timing my consumption of carbs each day. I generally try to stay at 20-30g daily and never go over 50g, but I wonder what would happen if I ate 40g carbs each in three meals spaced out enough during the day to be cleared by the next meal if I could get to 120g of clean carbohydrates and still be in ketosis. Is there any research that has looked at this? I’ve personally seen it happen in me consuming as many as 150g carbs in a daily strategically spaced out and still showing solid ketone readings. I believe this is something that should be explored that perhaps seasoned low-cabers could be ingesting more than the standard no more than 50g carbs daily.

Thanks for talking about this.


Apr 4, 2019

In Episode 144 of Keto Talk, Jimmy and Dr. Will Cole dig into the subject of Functional Medicine and Dr. Cole explains to us exactly what tests every keto dieter should be running and what they mean to you.

“It's rarely one thing that is the magic bullet. Normally it's a confluence of different factors. These labs allow us to find the pieces of the puzzle.” – Dr. Will Cole

“You can take a shotgun approach with labs and do everything, or use them to really fine tune your health.” – Jimmy Moore

The specific tests we talk about in this episode and the ranges you should be looking for:

C-reactive protein

Inflammation is one primary way disease genes get turned on, and it is generally destructive all over the body. C-reactive protein is an inflammatory protein that, while it is essential for cleaning up bad bacteria, in excess it can lead to accelerated aging, chronic disease, and damage to the telomeres.

Optimal Range: < 0.5 mg/L

Small dense LDL particles

What you thought was “bad cholesterol” (LDL) isn’t all bad, and labelling it so is a simplistic and inaccurate view of cholesterol. LDL particles are proteins that carry cholesterol around in your body. Some of these particles are big and buoyant, while others are small and dense. It’s the small dense LDL particles that can cause damage, while the larger fluffier particles are essentially benign. Knowing your level of small dense LDL particles is much more instructive that simply knowing your total cholesterol, because it is the small dense LDLs – not the cholesterol itself – that indicate a riskfor heart attack and stroke (and thereby put you at risk for an earlier death).

Optimal Range: < 200 nmol/L


This protein in excess (especially when coupled with a B vitamin deficiency) has been linked to cognitive decline, which can drastically reduce quality as well as length of life.

Optimal Range: < 7 Umol/L

Hgb A1C

This test tells you what your blood sugar has been, on average, for the past two to three months. When it is high, it can indicate pre-diabetes or diabetes, and an elevated A1C has been linked with higher rates of all-cause mortality in patients with diabetes.

Optimal Range: < 5.3%

Vitamin D

This nutrient is responsible for hundreds of different genetic pathways in the body but because most people spend most of their day indoors and get little sun exposure, vitamin D deficiency is rampant. That’s too bad because this deficiency is linked to chronic disease, and optimal levels are linked to an actual preservation of telomeres, meaning you live longer and stay healthier! If that’s not a reason to get a little sunshine, I don’t know what is. Note that vitamin D should be paired with other fat soluble vitamins, like vitamin A and K2, for maximum absorption.

Optimal Range: 50-60 ng/mL

Fasting insulin

When your body breaks down carbohydrates, and to a lesser extent, proteins into glucose, your blood sugar goes up. In response, your pancreas secretes insulin to send your blood sugar into your cells (for energy) and bring down the level in your blood. However, if insulin gets activated too often at too high levels, this has been linked to accelerated aging and telomere shortening.

Optimal Range: < 3 ulU/mL

C-peptide: Optimal Range: 0.8 to 3.1 ng/mL
Fasting blood sugar: Optimal Range: 75 to 90 mg/dL
Triglycerides: Optimal Range: < 100 mg/dL
HDL: Optimal Range: 59 to 100 mg/dL

Hormone testing: Urine and Saliva
Other Nutrients: Selenium, Mg, Iron, MMA,

Microbiome labs: We look to assess gut health, where around 80 percent of our immune system resides.

Intestinal permeability lab: This blood test looks for antibodies against the proteins that govern your gut lining (occludin and zonulin), as well as bacterial toxins that can cause inflammation throughout the body, called lipopolysaccharides (LPS).

Multiple autoimmune reactivity labs: This array shows us if your immune system is creating antibodies against many different parts of the body, such as the brain, thyroid, gut, and adrenal glands. The labs are not meant to diagnose an autoimmune disease, but to look for possible evidence of abnormal autoimmune-inflammation activity.

Cross reactivity labs: Helpful for people who are gluten-sensitive and who have gone gluten-free and eat a clean diet, but still experience symptoms like digestive problems, fatigue, and neurological symptoms. In these cases, relatively healthy food proteins—such as gluten-free grains, eggs, dairy, chocolate, coffee, soy, and potatoes—may be mistaken by the immune system as gluten, triggering inflammation. To their immune system, it’s as if they have never gone gluten-free.

1. AHCY:

This enzyme is responsible for breaking down the amino methionine by converting S-adenosylhomocysteinase into pro-inflammatory homocysteine. Mood disorders are common for those with a double mutation but typically do well with SAMe supplementation.

2. BHMT:

The BHMT gene directs the enzyme responsible for the amino acid methionine, the building block in the choline oxidation process for optimal brain function. Changes in this gene are associated with ADHD.

3. CBS

No, not the television network! It actually stands for the enzyme that makes the amino acid cystathionine. A mutation of this gene will lead a person to produce more sulfur end products and as a result will need to limit sulfur-rich foods such as legumes and dairy. These foods can increase ammonia levels and contribute to existing health problems. NOS and SUOX are two other genes that can increase sulfur and are linked to immune disorders like asthma.

4. COMT:

This gene is responsible for creating a healthy balance of neurotransmitters and, in turn, a healthy brain. A double COMT gene change is associated with increased risk for anxiety, OCD, bipolar disorder, and ADHD.

5. MAO:

The main role of the MAO gene is to clear out excess neurotransmitters like serotonin. When changes to this gene occur it can create an imbalance in neurotransmitters leading to increased rates of anxiety and depression. Those with an MAO mutation, as well as the MTHFR gene mutation, can have a higher rate of histamine intolerance. Because of this even healthy foods such as fermented foods, bone broth, and vinegar can increase inflammation.


This is not an acronym for a swear word guys, get your mind out of the gutter. The biggest thing I use DNA testing for is to assess methylation, a biochemical superhighway that help your gut, brain, hormones, and detox pathways function properly. This process happens a billion times every single second so if methylation isn’t functioning well, neither are you. Since I often deal with a variety of gut, brain, and hormonal problems in my clinic it is important to see if my patients methylation is working well.

The MTHFR enzyme is responsible for converting folic acid into folate which acts as fuel to the methylation process. A1298C and C677T are the two main MTHFR mutation. When A1298C is altered it can lead to mood disorders due to its important role in neurotransmitter function. C677T changes can cause higher levels of inflammatory homocysteine. Both of these are linked to autism and autoimmune conditions like autoimmune thyroid issues.


These are necessary for B12 production, another methyl donor. Those who have this mutation need higher intake of B12 because their body uses it faster than it produces it. Oftentimes people who have this genetic change can also be low in lithium which is needed for mood regulation. We can easily check lithium levels through testing blood and hair.

8. VDR

VDR stands for vitamin D receptor. Every single cell in your body uses vitamin D. Other than your thyroid hormone, no other nutrient or hormone can claim that importance. It is responsible for over 200 different pathways in the body. Mutations in this gene make it really difficult to absorb vitamin D. It’s important to know if this is the case for you in order to supplement higher doses on a consistent basis to make sure you are getting enough of this vital nutrient.

9. Detox genes

I also look for changes in your detox genes such as CYP1A2, also known as your caffeine gene. This can show just how well you can tolerate caffeine and whether or not it can be harmful or beneficial to your health.

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