Keto Talk With Jimmy Moore & Dr. Will Cole

Veteran health podcaster, blogger, and international bestselling author (Keto Clarity and The Ketogenic Cookbook) Jimmy Moore from "Livin' La Vida Low-Carb" and Pittsburgh, PA-based functional medicine practitioner Dr. Will Cole from discuss the current health headlines, dissect the latest medical and nutritional health research studies, and answer listener-submitted questions about the low-carb, high-fat, ketogenic diet. Submit your keto questions at
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Keto Talk With Jimmy Moore & Dr. Will Cole






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Dec 15, 2016

If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing cohosts are shooting them down one at a time. Keto Talk is cohosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from "Livin' La Vida Low-Carb" and Arizona osteopath and certified bariatric physician Dr. Adam Nally from "Doc Muscles" who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions--send an email to Jimmy at And if you're not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. Listen in today as Jimmy and Adam celebrate this final episode of the year by answering 20 of your questions on low-carb, high-fat, ketogenic diets today in Episode 47.

**THANK YOU to Cecilia, Ken, Patrice, and Kristin**



Here’s what Jimmy and Adam talked about in Episode 47:

- Thriving on raw eggs, world's oldest person marks 117th birthday in Italy

1. Do I need to detox my liver and gallbladder before attempting to go keto?

Hello Jimmy and The Doc!

Ever since I decided to adopt a ketogenic lifestyle, I’ve wondered if I should do a number of liver and gallbladder flushes before trying to get keto-adapted? It’s usually recommended to eat low-fat for a few days during this flushing period so that would likely kick me out of ketosis anyway. I feel like my body has a difficult time detoxing and I wanted to do a series of liver flushes to get my liver working optimally again.

I am a Holistic Lifestyle Coach and have the ability to run labs for liver function. My mother, grandmother, and great grandmother have all had to have their gallbladders removed and I want to keep mine! Would really love to hear your thoughts on this.

Thank you so much for all of your work!

Kind Regards,


2. Is using exogenous ketones an effective way to boost ketones when they are at their lowest?

Hey guys,

Is there any emerging research on what the most effective dose of exogenous sources of beta-hydroxybutyrate should be? And what is the best time of day to use them? Through my own N=1 experimentation, I have found that I'm out of ketosis for about 3 hours after I wake up in the morning. Then by midday I'm right back into ketosis with levels steadily increasing as the day goes on. After working out in the evenings, I am usually in the red zone on the Ketonix.

But then by the following morning I'm back to green again. So I'm wondering if I should take a supplement like KETO//OS in the mornings upon waking up since this is when my levels are naturally at their lowest or if I should take it in the afternoon or evenings to accentuate my natural rhythm. Are there any studies looking at the relationship between circadian rhythms and ketones or the use of exogenous ketones that could help me in my situation? My purpose in eating ketogenic is disease prevention and anti-aging.



3. Is my depression preventing me from getting the full benefits of keto? Do depression drugs work differently in the presence of ketosis?

Greetings gentlemen,

I’m sure many people who are trying the ketogenic diet suffer from major depressive disorder. I recently stayed in nutritional ketosis averaging 1.0-5.0 mmol/L and heavily supplemented with electrolytes for 5 weeks but did not experience the increased energy that I hear being reported by others. Although I lost weight and didn’t have to eat as often, I still had some pretty intense carb cravings.

Could my depression be interfering with the benefits of nutritional ketosis? And if I push through these cravings now, will remaining in a ketogenic state eventually help me deal with the depression? I also wonder what some of the most commonly-prescribed selective serotonin reuptake inhibitors such as Lexapro, Prozac, and Zoloft do in conjunction with keto to interact and work differently than a standard diet.

Thanks for any insights,



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4. Can I use green banana flour resistant starch and stay in ketosis while taking care of my microbiome?

Hey Jimmy and Adam,

I'm starting on a new health mission to feed and nurture my microbiome. The mechanism for this feeding is a daily high-fat smoothie that contains coconut milk, protein powder, MCT oil, some berries, and banana flour resistant starch to make a high-fat, moderate protein, low-carb keto smoothie. I have a few questions for you guys about this:

- Is this Green Banana Flour Prebiotic Resistant Starch keto-friendly? I've read on the Internet that the starch does not spike blood sugar. Is that true? The product I'm using has 7.5 grams of carbs per tablespoon. What say you?

- Will resistant starch on a ketogenic diet over time transform my microbiome from being fat to lean?

- Do you have additional suggestions or thoughts for the care and feeding of the microbiome while remaining in a state of nutritional ketosis?

I look forward to listening to your podcast every week as I'm truckin' down the road. You always have little nuggets of info that I can apply directly to my keto lifestyle.

With much regards from your fellow Healthy Ketonian,

Truckin' Chuck

5. Is taking L-Glutamine a good or bad idea when you are on a ketogenic diet?

Hi Jimmy and Dr. Nally,

Thank you for your podcast and I never miss an episode of Keto Talk. I have been eating LCHF for 4 months and have lost 40 pounds so far. I have become interested in taking it to the next level with ketogenic and I am having a hard time getting into ketosis while my weight loss has stalled out. I am taking 8 grams of L-Glutamine a day on the recommendation of Maria Emmerich from one of her books and it definitely seems to help me with sugar cravings. But I heard that L-Glutamine can turn into sugar through gluconeogenesis. Now I'm totally confused and need your help to clear up whether I should be taking this supplement or not. 

Thanks so much,


6. Why is my blood pressure still so high despite cutting my carb intake?

Hi Jimmy and The Doc,

I enjoy your show and like hearing about all your experiences and advice concerning keto living. It seems that most people are able to lower their high blood pressure readings very quickly after cutting their carbs. But this has not occurred in my case, even after a year or so. I did hear that there could be other reasons apart from eating high-carb that could lead to high blood pressure. What are they?

Thanks again for your great show,


7. Should I be concerned about toxins from filter fat in my bacon grease fat?

G'day Jimmy and Adam,

A huge THANK YOU for your helpful and informative podcast and for being so generous with your experiences and knowledge beyond this podcast! You both are changing lives for the better!

My question relates to cooking for a ketogenic lifestyle. I hear many people suggesting cooking with bacon grease or bacon fat as we call it here in Australia. I was talking to my local butcher about and mentioned that I cook with bacon fat and he became very alarmed by this. He explained that there are two types of animal fat—one healthy that is what he describes as clean fat and one not so healthy which he calls filter fat. The filter fat contains massive amounts of toxins which is why my butcher recommends cooking with lard or tallow sourced from fat around the kidneys.

Is this something Ketonians should take into consideration or not? Personally I tell people to eat the best your budget will allow and this isn't always organic and grass-fed. We eat bacon everyday and I'm certainly not changing that habit. But maybe the idea of reusing the bacon fat saved from cooking our morning bacon isn't such a good idea after all. I just thought I would bring this up as it is relevant to those of us in the keto community. What are your thoughts?

Sincerely loving the keto lifestyle,

Peter and Susie in Australia


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8. Why is peanut butter demonized and almond butter glorified on a ketogenic diet?

Hi Jimmy and The Doc,

I’d like for you guys to settle the seemingly neverending debate about why peanut butter is technically not keto,and why almond butter is so much better. The carb difference between the two is negligible assuming you’re getting a nut butter that has no sugar added to it and the fatty acid profile doesn’t look dramatically different either. I do notice that almond butter has a SLIGHT advantage over peanut butter in the omega 3 to omega 6 ratios but both are very low on omega 3’s as compared to their respective omega 6 ratios. And both look to be within .5 grams of polyunsaturated fat per 1 oz. serving.
So why does peanut butter get demonized while almond butter looks to be a very similar food from a nutritional perspective? I thought this would be a fun topic for you guys to cover on Keto Talk as I know this has been a hot topic of debate on the Internet within low-carb and ketogenic circles.

Thanks for the insights,


9. Does being in a ketogenic state produce complications with taking birth control pills?

Dear Jimmy and The Doc,

Thank you for your outstanding podcast because it adds so much value to my life. I have a question that I hope you can help me with. My girlfriend has joined me in eating a well-formulated ketogenic diet for just over a month and she feels fantastic in almost every way. The only problem is her period has arrived sooner than it usually does and lasts longer, too. When it happened once, she thought it was an anomaly but then it happened again. She is taking birth control (Lutera) and always had regular and consistent periods while on the pill with little to no side effects.

Are there any potential complications with taking birth control while on a ketogenic diet? If the birth control is causing this issue, what alternatives does Doc Nally recommend? Or will all of this come back into balance with time?

Thank you so much for your help and thank you again for your valuable work.

Yours truly,


10. Are there any studies looking at ulcerative colitis and a ketogenic diet?

Hello Jimmy and Doc Nally!

Love the show, especially when you two tackle the latest research, and I have been a faithful listener and Ketonian since I discovered your show back in March!

I have a family member who is suffering from ulcerative colitis and I was wondering if you guys might be able to shed some light on this disease and how a ketogenic diet might improve or reverse it. Is there any research on using a nutritional therapy like keto to treat it or are people doomed to be on medications forever?

Thank you so much for all of the wonderful work you do!


11. Does a high-fat diet like ketogenic increase inflammation in the prostate?

I have been having some serious prostate problems and they seem to be getting worse on the keto diet which I've done for about 6 months. My blood work is great though. I ran across a study from the American Urology Association that states that high-fat is inflammatory for the prostate: see page 3 of 4 under Epidemiology

I am losing my mind over this prostatitis. It’s very painful even though the doctors all say they cannot find anything. Maybe I am the one in a million exception to the rule where eating high-fat does not work for me. Anyways, any feedback you might have would be greatly appreciated.

Thanks for all your help,


- Cancer spread is increased by a high fat diet, ground-breaking evidence shows

12. Is there any issue with someone taking a fat-burning supplement while eating ketogenic?

Hi guys,

I've listened to the majority of your episodes and I think I have a topic you haven’t addressed yet. What are your thoughts about the plethora of stimulant-based fat-burning supplements that are being marketed out there? I've heard Dr. Atkins scolded his patients very earnestly in his practice for "cheating" instead of just believing in the diet. You can never really be sure that these supplements actually contain the intended ingredients, but the fact is these stimulants typically are intended to stimulate catabolic hormone pathways supposedly to enhance fat burning and "promote thermogenesis" (in the calorie counting paradigm). But if you're insulin resistant in some way, isn't it probably a really bad idea to be spiking catabolic hormones all willy-nilly when part-and-parcel of insulin resistance is an impaired ability for insulin to control these hormones at the expense of letting your body find the right levels through the ketogenic diet itself?

Thank you for answering my question and I have been enjoying listening to the show a lot.




NOTICE OF DISCLOSURE: Paid sponsorship

13. Does an increase in Vitamin D levels diminish ketone levels in the body?

Hello Jimmy and Dr. Adam,

I have a simple question for you: Does Vitamin D impact ketones? I only ask this because I have noticed a few times some noticeably lower ketone readings after a long day in the sun. I have a feeling movement while outside is also playing a role in this. Any thoughts on this?


14. Is a ketogenic diet an acceptable nutritional therapy for people with organ transplants?

Hello Jimmy and The Doc,

I’m wondering about the impact of a ketogenic diet for organ transplant recipients. I had a liver and kidney transplant in 2001 and was starting to experience problems after about seven years when my husband and I switched to a low-carb diet and very quickly saw all my markers improve. We’ve been eating this way since 2009 and we’re both in great shape. I’ve been telling my nephrologist and my hepatologist what I’m doing, but I can’t persuade them to recommend this way of eating to other transplant patients. Am I just lucky to see my health improve eating keto or could this help other transplant recipients, too?



15. What do I need to do to experience the robust energy that is supposed to come from ketosis?

I’ve been more or less keto for over two years now and I have to say I don’t really have a “feeling” of when I’m in ketosis. My energy level never really went up all that much and I hear people talk about how great they feel in ketosis. The truth is I’m envious of them because I’ve never experienced this myself. I know there are a LOT of things that relate to energy level: stress, emotional issues that can drain a person, thyroid, electrolytes, etc. How can someone like me who is keto obtain the typical energy level that other Ketonians are experiencing? Where would you start and what would you want to rule in or out? I have a very low CRP, no calcium in the heart, TSH normal and more.

Thanks for helping me figure this out!

Dr. Jim


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16. Is eating a high-fat diet without significantly reducing carbohydrates a concern for cardiovascular health?

Hi Jimmy and Doc Muscles!

I’ve been listening to Keto Talk since the beginning and really enjoy the banter between you two! You both do a great job of making all the information you provide easy to understand. I have a question that seems to have been answered in a roundabout way previously on your podcast. But I would love an answer that is specific to my concern.

I have been dealing with autoimmune issues for a few years now. Psoriasis since my 20s, and possible rheumatoid arthritis for about 2 years now. I’m 40 years old and had always followed recommended dietary guidelines, but that didn’t prevent these issues from happening. I follow a mostly AIP, lower-carb diet, but I know that I am not in ketosis most of the time.

My carbs include small amounts of fruit (usually about 1 serving per day), sweet potatoes, and all vegetables. I sometimes make AIP friendly treats that are low in sugar, but do contain some starch. I now eat higher amounts of fat than I ever have from Kerrygold butter, cream, avocados, coconut oil and olive oil. I feel really good most of the time and love how I can wait longer between meals and don’t seem to get hangry. I stay quite active, work standing up, kick box 2-3 days per week, do a little yoga, and still mix in a little running, biking and swimming from my triathlon days.

My question for you guys is this: If I am not in ketosis most of the time while eating 50-100 grams of carbs with my higher consumption of fat, am I jeopardizing my cardiovascular health? I don’t believe I have a blood sugar issue. I test it sporadically, and even after a higher carb meal, it is under 120. My total cholesterol jumped from 208 to 269 during the last 3.5 years, LDL went up to 139, triglycerides in the 50s, HDL in the 90’s. Of course, my HMO doctor wants me to retest in three months because it is so high.

Thanks so much! I wait anxiously for your new episodes every week! You guys are great!


17. Can toxins released from fat stores while eating keto lead to eczema?

I’ve been doing keto really well and keeping my daily carbs under 20 grams and I feel great. My energy and mental clarity are awesome and my waist has dropped from a size 41 to a size 35 in only 6 months. But I've developed a serious and painful case of eczema on my feet. These blisters are huge and my guess is that my body was holding onto toxins in my fat cells which are now being released and overloading my body leading to the eczema. Am I right about what’s happening or is there some other mechanism at work with this? If it is toxins being dumped into my bloodstream, then what is the best method to deal with this? Should I slow down on my ketogenic diet or should I attempt chelation or some other method to bind and remove these toxins.

Thank you for everything you do!


18. Is it better to have a little bit of real sugar sources instead of sugar alternatives?

Dear Jimmy and Adam,

For long-term health, I eat low-carb/higher fat and I prefer to eat whole foods. So when I see recipes that use erythritol, stevia, and similar sugar alternatives, I replace those with honey, pure maple syrup, molasses, table sugar, and brown sugar instead. I also cut the amount of sugar in recipes by about 50-70% or sometimes omit the sweetener entirely.

Erithrytol and other "tols" also upset my stomach and gut. What so you think about using small amounts of "real" sugars as I described? I am fortunate to have a healthy metabolism and can tolerate a few more carbs than my husband, for example, who is carb-sensitive like you guys. Would a small amount of a sugar (say 2 Tbs total at the most) be too much for him?

Thanks guys! I love Keto Talk and am a big fan.



Maria's latest book releases on December 27, 2016

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19. Do you get all the gut health benefits of eating spinach if it is cooked vs. raw?

Dear Jimmy and Doc Nally,

Does it matter If I eat my spinach cooked in butter versus raw? I am trying to eat the two cups of spinach daily for gut health that Dr. Nally recommends.

Thank for all you do!


20. What, if any, impact does the use of cannabis have on ketosis?

Hey guys!  I love your show and I've learned so much from it—so thank you.  Now my controversial question: Medical and recreational cannabis is starting to become legal in many states, so I have to ask this—does cannabis use have any effect whatsoever on ketosis or a ketogenic diet?

Thanks for addressing this!




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- Jimmy Moore from "Livin' La Vida Low-Carb"
- Dr. Adam Nally, DO from
- Thriving on raw eggs, world's oldest person marks 117th birthday in Italy
- Cancer spread is increased by a high fat diet, ground-breaking evidence shows

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