Keto Talk With Jimmy Moore & Dr. Will Cole

Veteran health podcaster, blogger, and international bestselling author (Keto Clarity and The Ketogenic Cookbook) Jimmy Moore from "Livin' La Vida Low-Carb" and Pittsburgh, PA-based functional medicine practitioner Dr. Will Cole from discuss the current health headlines, dissect the latest medical and nutritional health research studies, and answer listener-submitted questions about the low-carb, high-fat, ketogenic diet. Submit your keto questions at
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Keto Talk With Jimmy Moore & Dr. Will Cole






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Apr 25, 2019

In Episode 147 of Keto Talk, Jimmy and Dr. Will Cole do a deep dive on the subject of offal and why it is so important to eat 'nose to tail'.

“Especially for people following the carnivore protocol, this is great because offal is one of nature's multi vitamins.” – Dr. Will Cole

“When you think back to our hunter gatherer ancestors when they got an animal they didn't let any part of it go to waste.” – Jimmy Moore

Offal and organ meats are most popular when used from beef, pork, lamb, or poultry. The different kinds of organ meats that you can eat include:

  • Brain
  • Heart
  • Liver
  • Kidney
  • Tongue
  • Gizzard
  • Sweetbread

History Of Organ Meats

Each culture has their own opinion of organ meat and each views it slightly different than the next. In some cultures, organs are consumed daily while in others certain organs are illegal to eat. One thing that stands true for all cultures is that organ consumption has changed over the years.Centuries ago, not only were organ meats just eaten, they were praised and loved. When food was hunted and gathered there was a lot of effort put into supplying it for families and tribes. Hunters didn’t just walk to the local supermarket to buy meat, they had to fight for it. And when you’re putting that much effort into hunting food for your family, you use every ounce of it that you can. Not only was it eaten just so it wouldn’t go to waste, the organ meat was reserved for the respected society members. Whether it was the political kings and leaders, the hunters, or the elders; the organ meats were regarded as the best and saved for the best.

Over the years it has changed to be eaten by all, not just the well respected, in almost all countries. In some countries, organ meats are served as common street food and others as appetizers and entrees in expensive restaurants. No matter how common throughout the world though, eating organ meat isn’t a widely loved meat here in the United States, yet.

Why People Avoid It

I will admit that the taste can take some getting used to, but they provide far too many benefits to avoid it. Another reason that organ meats invoke negative perceptions is the thought of toxins. The misconception in our society is that the animals’ toxins are stored in their organs; and when eaten, the toxins now move into our bodies. This would make sense, however the toxins are not actually stored in an animal’s organs. The organs, the liver in particular, are where the toxins move to get filtered out. Once there, the liver doesn’t store it, but rather decide where it should be moved to. Most times, the liver moves any toxins to the kidneys where it is then expelled through urine. The toxins are removed from the animal’s organs and bodies before it has the chance to enter our bodies.


The benefits of eating organ meat reach far and wide. Each one acts as a superfood that provides many more nutrients to our bodies than the animal muscle meat that we normally eat.

1. CoQ10

One of the main nutrients that organ meats offer is the Coenzyme Q10, otherwise known as CoQ10. This coenzyme is found in the largest amounts in animal hearts. Like all coenzymes, our bodies naturally produce this nutrient, but only in small amounts and not enough that we need. That’s where organ meat comes in.

CoQ10 is also designed to help other enzymes digest and break down food. When it comes to energy, it isn’t always the same and instead comes in many different forms. The form that our cells use is called adenosine triphosphate, or ATP. But when our energy comes in the form of fat or carbohydrates that we eat, how does our body make that change to supply energy to our cells? CoQ10 is crucial for the body to begin and sustain the ATP synthesis process to continually supply our cells with energy each day.

Our brain and cardiovascular systems are also impacted by this coenzyme due to its antioxidant features and its effect on oxidative stress. Although further research is needed, it is recommended to people with or at risk for cardiovascular disease to up their CoQ10 intake along with regular medications. Eating foods high in CoQ10 helps fight the backlash that come with these prescribed medications and keep blood flowing.

When it comes to our brain, it has been shown that those with cognitive disorders have lower levels of CoQ10 that contribute to the issue. As potential agents are looked for to combat the cognitive decline we see on a daily basis, research suggests that CoQ10 has potential to be used medically to fight the decline.

2. Vitamin A

Organ meats also offer one of the largest amounts of the antioxidant Vitamin A. When taken in supplement form Vitamin A in mass amounts can result in toxicity; but, Vitamin A present in food does not lead to any toxic results even in large amounts. When the body breaks down nutrients from food sources it can access how much our individual bodies need and expel any extra, avoiding any issues.

There are two types of Vitamin A: retinol, or active Vitamin A, and beta-carotene. Active Vitamin A is present in organ meats and other animal meat in smaller quantities. This type can be broken down and used by the body right away, making it a perfect source to get this nutrient from. Beta-carotene, found in many vegetables, cannot be used by the body unless broken down and changed. Even though vegetables are great for you, they are an inefficient source of Vitamin A because of the work and stress it has on our bodies just to use it.

Vitamin A can also do a lot of good when it comes to the immune system. In a recent study of children under 5 in Colombia, they came to the conclusion that increasing the childrens’ Vitamin A intake was the most effective way to protect against disease. Not only was it the most effective, it was also the least expensive way to protect the immune system in the children to ensure health. When Vitamin A is present, the mucosal barriers that become damaged by infection can regenerate and repair themselves to provide immune protection. If your body is lacking this immune-boosting vitamin, then regeneration does not occur and infections become more prevalent and can spread faster.

One of the most noticeable benefits of Vitamin A is the glowing and clear skin it can lead to. Its support of cell regeneration keeps wrinkles away while the anti-inflammatory properties protect against acne and skin irritations.

3. B Vitamins

Organ meats also supply us with important B Vitamins. All of the B Vitamins that are present in organ meats offer some kind of help to our cardiovascular systems. These vitamins can maintain healthy levels of cholesterol, blood pressure, blood triglycerides, and homocysteine. When all of these are at healthy levels, the risk of developing a heart or cardiovascular issue is greatly diminished.

Vitamin B7, also referred to as biotin, is known for its ability to enhance beauty through the positive effects it has on hair, skin, and nails. One thing needed for radiant skin is fatty acid synthesis, and, of course, biotin aids this process and can therefore fight the effects of aging and prevent wrinkles.

Biotin deficiency and thyroid problems can both lead to thinning hair and hair loss. This can be reversed and restored through incorporating more biotin into your diet. The same is true for restoring weak and thinning nails back to full health. For this reason many beauty products and beauty enhancing supplements can be found with biotin. However, biotin is not as effective when use topically compared to when it is when ingested. 3 ounces of beef liver provides 30 mg of biotin, which is the daily recommendation for adults.

The B Vitamins in organ meats also aid in hormonal health and pregnancies. Folate, otherwise known as B9, is one of the most needed vitamins for mothers and babies for a healthy pregnancy. Folate supplements are often recommended by doctors, but I truly believe that when available, food medicines are the best way to get your daily dose of vitamins. Vitamin B6 can also decrease the risk of erectile dysfunction, reduce nausea related to pregnancy, and calm menstrual cycle cramps.

Vitamin A for immune system calming.

Vitamin A is essential for a strong immune system, and vitamin A deficiency has been linked to autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. Researchers suspect the reason has to do with our dendritic cells, which send out a “red alert” at the sign of a supposed invader, to stimulate immunity, or a “calm down” message that tones down excessive and damaging immune reactivity. The “calm down” message makes use of vitamin A!

Vitamin K2 for brain and spinal cord healing.

One study in the Journal of Neuroimmunology found that vitamin K2 was effective at inhibiting the pro-inflammatory iNOS in the spinal cord and the brain immune system in rats that had multiple sclerosis symptoms. That suggests it could do the same for humans, but unfortunately, K2 is one of the most common nutrient deficiencies in the western diet. You can fix that with the right food medicines!

Iron to replenish deficits.

Iron deficiency anemia (IDA) is linked to many autoimmune diseases, but it isn’t clear how much of this is cause and how much is effect. One likely reason is that ferritin (stored iron) is mostly absorbed in the intestines. When absorption is compromised by inflammation and autoimmunity, iron stores can fall too low, and as you may already know, damage to the gut lining and leaky gut syndrome are considered (in functional medicine) to be preconditions for autoimmunity.

Micronutrients to quell inflammation and promote optimal function.

Micronutrient deficiencies – especially of selenium, magnesium, and zinc – are associated with several autoimmune diseases. That’s likely primarily due to chronic inflammation, which decreases the absorption of these vital nutrients. Yet, these micronutrients are required for the healthy production and conversion of the thyroid hormone, and thyroid problems such as Hashimoto’s disease are some of the most common autoimmune conditions. Supplementing with these micronutrients can help get thyroid issues back on track as you work on healing the gut and decreasing inflammation to increase micronutrient absorption.

Apr 18, 2019

In Episode 146 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Healing Chronic Fatigue, Elevated Glucose Response To High-Carb Meal While Keto, APAO2 Gene, Keto & A-Fib, Daily Laxative For Opiate-Induced Constipation, and more!


  • Will's exciting new podcast The goop Fellas Podcast
  • Why is being proactive about your health by doing things outside of conventional wisdom considered strange?
  •  How do you mitigate the effects of cortisol and insulin resistance (even while eating keto) induced by taking prednisone for Crohn’s disease?
  • What role could a ketogenic nutritional health plan play in the recovery from opioid addiction?
  • What’s the difference between saturated, monounsaturated, and polyunsaturated fats and how much of each do you need in your keto diet?
  • Should a Type 1 diabetic who eats keto and sees a major glucose rise from a powerlifting workout be concerned about the rise in glucose?
  • How do I eat low FODMAP real food-based keto to control my IBS when my doctor tells me the fat-digesting bile is flowing back into my stomach?

“At one point when I was on Lipitor before starting the Atkins diet I got my cholesterol down to 120, but you can ask my wife, I was NOT a happy man.” – Jimmy Moore

“With the rise in awareness in wellness you also have a rise in skeptics and trolls. You can be objective without cynical and name calling.” – Dr. Will Cole


– How do you heal fibromyalgia and chronic fatigue when you’re doing everything perfect in your ketogenic lifestyle?

Hi guys,

I’m a longtime listener listener and appreciate all of the information you give so generously! I’m trying to figure out how to heal from fibromyalgia and chronic fatigue syndrome which I was diagnosed with in 2014. I have eaten an LCHF diet for many years and lost around 30kg (~66 pounds). I'm 59 years old and have been a yo-yo dieter my entire life. On low-carb, I have been much more successful in stabilizing my weight and the trend has been moving slowly in the right direction with about 22 pounds left to go. It’s such a struggle. Even still, my fasting blood glucose is 5-6 mmol/L and blood ketones are 0.5-0.9 mmol/L.

I’ve been very strict in my keto diet for a while, but the aches and pain in my arms and legs from my fibromyalgia and chronic fatigue persists. The good news is my brain is a lot clearer and I’m able work again. It’s so difficult to find any doctors here in Sweden willing to run the tests I need to dig a little deeper into this. What would you suggest I do to help with my health issues? Thanks for your input.

Susan from Sweden

– Why is the blood glucose response to a higher-carb meal greater since I’ve gone strict keto than it was when I was only eating low-carb?

Hey Jimmy and Will,

Can you explain more about the blood glucose rebound effect that happens after eating keto for a while and then having a higher carb meal? I’ve noticed much higher blood sugar readings when I eat carbohydrates while on a ketogenic diet than I did just eating low-carb. I suppose it’s sign that my insulin resistance has gotten worse, but I can’t imagine why since I’m on keto. Granted, it is not always perfect in my keto diet and I don't track macros anymore. But my normal readings two hours postprandial might have been 130 before but now it’s 160.

Good luck with your six-month sabbatical, Jimmy. And thank you for answering my question.


– How can I optimize my keto lifestyle with the APAO2 gene mutation that makes it difficult to process saturated fat?

Hi Jimmy and Dr. Cole,

I have been keto for a year and a half and I’ve lost 60 without taking any medications. I recently learned that I have the APAO2 gene mutation that makes it difficult for my body to process saturated fat. My doctor insists that I cut my fat intake and eat a lot of vegetables. My LDL-P is 2418 and my heart calcium score came in very high at 268. I also have high oxidized LDL. I’ve been dairy-free for a year which has helped me boost my HDL cholesterol to an all-time high of 49. I took statin medications for almost 18 years before the side effects became too much for me to bear. I’m 68 years and just want to be as optimally healthy as I can possibly be. The one bright spot is my inflammation marker hsCRP is stellar at 0.3.

Should I be eating more lean proteins and increasing my intake of avocado, olives, and nuts along with eating more leafy greens?  I am considering the Ketotarian way of eating since it seems to fit my genetic needs at this time. I just hate to give up so many of the animal-based foods I enjoy.

Thanks for your help,



– Will a ketogenic diet help patients dealing with atrial fibrillation?

Hi Jimmy and Will,

I just listened to your special episode with guest cohost Dr. Jay Wiles from a few weeks back where you discussed the bogus a-fib study. As someone who has this condition, I appreciated your input on that. But you guys didn’t say whether keto would help with this disease or not.

My experience has been that my heart palpitations get worse eating keto and that if I backed off my thyroid medication I get relief from this. I’m not sure why, but I suspect it is the hormone regulatory effects that come from a ketogenic diet. Unfortunately, when I did this my TSH shot way up to (yes, that’s not a typo—338!), and my doctor was obviously VERY concerned. I went back on the medication for fear of not knowing what impact chronically high TSH would have on the body. (I live in Canada and doctors rarely test any of the other numbers on the thyroid panel).

Can you talk more about what impact eating keto has on patients with a-fib? Thanks so much.



– Is using senna leaf as a daily laxative to deal with opiate-induced constipation causing damage to the microbiome and general gut health?

Hey guys,

I eat >keto, but have a really bad case of opiate-induced constipation which forces me to use senna leaf as a laxative on a daily basis.  I try to boost my gut health with fermented foods, probiotics, and digestive aids. But it seems I’m hopelessly addicted to taking laxatives since I can’t poop without help. This is probably a silly question, but is my microbiome suffering from this? I haven’t had a solid stool in months. So embarrassing!

Thanks for helping me with this!


Apr 11, 2019

In Episode 145 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Persistent Itchiness, Bladder Pain While Eating Keto, Primary Hyperparathyroidism, Being Ravenously Hungry When Cutting Protein, Meal Timing To Increase Carbohydrate Intake, and more!


  • Will taking daily Holy Communion impact insulin levels and my ability to burn fat and ketones?
  • Is it normal to experience intense heartburn after breaking an extended fast?
  • Other than meditate or quit my job, how do I deal with the stress-induced panic attacks and weight gain despite eating keto?
  • I’ve heard keto and dry fasting can help me with my tinnitus. Is there any scientific evidence supporting this?
  • Why would my blood glucose remain elevated even after a 72-hour fast?

“You have to decide what is more important to you; the stress of a certain job or your health.” – Jimmy Moore

“It doesn't have to be carnivore or vegan. Find what makes you feel the best. We lack a sense of nuance in our current culture.” – Dr. Will Cole


Jimmy and Will answer your questions:

– Why do I have a persistent itch ever since I started eating keto? What else can I try to try to deal with this?

Hey Jimmy and Will,

I have dealt with an extremely annoying itch all across my back, shoulders, and inside my arms ever since I started eating a ketogenic diet. I’ve tried eating no dairy, but the itching persists. I stopped taking as much of my vitamin C, but that didn’t solve the problem either. I highly suspect this is coming from oxalate dumping in my body as I eat lots of almond butter, almond milk, and raspberries as a keto dieter over the past seven months. I used to be vegan and added back in red meat after years of not eating it to help with my kidney health. Any suggestions about how to deal with this annoying itch?

Thanks for listening,


– Why would I experience cramping, bladder pain, and diarrhea when I eat a ketogenic diet?

Hey Jimmy and Dr. Cole,

I was eating a keto diet and loving along with my husband, but I started developing some cramping pain in my bladder and diarrhea as well as feeling an urgency and a burning sensation when I went to the bathroom. I went to see my doctor who gave me antibiotics and I saw only marginal improvement so we switched medications. This song and dance went on for about a month or so, but I decided to go off of keto to see if that would help. I slowly started feeling better from the bladder pain, but I sure miss the benefits I was getting from it. What could be causing this in my ketogenic eating plan?

Thank you for your wisdom and help.


– What impact is my Primary Hyperparathyroidism having on my elevated blood pressure and weight loss challenges while eating keto?

Hey guys,

I’m a 63-year old woman diagnosed with Primary Hyperparathyroidism one year ago. I have doing strict keto for the past six months with a few slip-ups during the holidays. I have lost 40 pounds and about 20 inches off my body with another 25 pounds of weight loss to go. The pain related to this disease has eased up since I started eating low-carb, high-fat, but blood pressure has still remained elevated requiring me to take medication. How is this disease impacting the blood pressure and my ability to shed the rest of the weight off my body?

A thankful Ketonian,


3. Why did I get ravenously hungry when I reduced my protein intake and raised my dietary fat consumption?

Hey Jimmy and Will,

I hear you guys talk about moderating protein and eating a higher percentage of fat in the diet to be keto. I’ve been eating this way for about a year and have lost a total of 95 pounds and getting stronger each day. I’ve been consuming around 130g protein daily and stalled out in my weight loss efforts at 220 pounds. I dropped my protein down to 90g and raised my fat to 285g attempting to eat this in an 8-hour feeding window (16 hours of intermittent fasting). It went well for a couple of days and helped me break my stall. But then out of nowhere I started having ravenous hunger like I haven’t experienced before being in a state of ketosis. I workout six days a week, so I’m very active. Do I need to raise my protein back up again to help produce satiety with my keto meals? Any help or advice you can give is appreciated.



– Could spacing out your meals allow for more wiggle room for a keto dieter to consume more carbohydrates than 50g in a day and stay ketogenic?

Hi guys,

I have been keto for many years and am curious about the role of timing my consumption of carbs each day. I generally try to stay at 20-30g daily and never go over 50g, but I wonder what would happen if I ate 40g carbs each in three meals spaced out enough during the day to be cleared by the next meal if I could get to 120g of clean carbohydrates and still be in ketosis. Is there any research that has looked at this? I’ve personally seen it happen in me consuming as many as 150g carbs in a daily strategically spaced out and still showing solid ketone readings. I believe this is something that should be explored that perhaps seasoned low-cabers could be ingesting more than the standard no more than 50g carbs daily.

Thanks for talking about this.


Apr 4, 2019

In Episode 144 of Keto Talk, Jimmy and Dr. Will Cole dig into the subject of Functional Medicine and Dr. Cole explains to us exactly what tests every keto dieter should be running and what they mean to you.

“It's rarely one thing that is the magic bullet. Normally it's a confluence of different factors. These labs allow us to find the pieces of the puzzle.” – Dr. Will Cole

“You can take a shotgun approach with labs and do everything, or use them to really fine tune your health.” – Jimmy Moore

The specific tests we talk about in this episode and the ranges you should be looking for:

C-reactive protein

Inflammation is one primary way disease genes get turned on, and it is generally destructive all over the body. C-reactive protein is an inflammatory protein that, while it is essential for cleaning up bad bacteria, in excess it can lead to accelerated aging, chronic disease, and damage to the telomeres.

Optimal Range: < 0.5 mg/L

Small dense LDL particles

What you thought was “bad cholesterol” (LDL) isn’t all bad, and labelling it so is a simplistic and inaccurate view of cholesterol. LDL particles are proteins that carry cholesterol around in your body. Some of these particles are big and buoyant, while others are small and dense. It’s the small dense LDL particles that can cause damage, while the larger fluffier particles are essentially benign. Knowing your level of small dense LDL particles is much more instructive that simply knowing your total cholesterol, because it is the small dense LDLs – not the cholesterol itself – that indicate a riskfor heart attack and stroke (and thereby put you at risk for an earlier death).

Optimal Range: < 200 nmol/L


This protein in excess (especially when coupled with a B vitamin deficiency) has been linked to cognitive decline, which can drastically reduce quality as well as length of life.

Optimal Range: < 7 Umol/L

Hgb A1C

This test tells you what your blood sugar has been, on average, for the past two to three months. When it is high, it can indicate pre-diabetes or diabetes, and an elevated A1C has been linked with higher rates of all-cause mortality in patients with diabetes.

Optimal Range: < 5.3%

Vitamin D

This nutrient is responsible for hundreds of different genetic pathways in the body but because most people spend most of their day indoors and get little sun exposure, vitamin D deficiency is rampant. That’s too bad because this deficiency is linked to chronic disease, and optimal levels are linked to an actual preservation of telomeres, meaning you live longer and stay healthier! If that’s not a reason to get a little sunshine, I don’t know what is. Note that vitamin D should be paired with other fat soluble vitamins, like vitamin A and K2, for maximum absorption.

Optimal Range: 50-60 ng/mL

Fasting insulin

When your body breaks down carbohydrates, and to a lesser extent, proteins into glucose, your blood sugar goes up. In response, your pancreas secretes insulin to send your blood sugar into your cells (for energy) and bring down the level in your blood. However, if insulin gets activated too often at too high levels, this has been linked to accelerated aging and telomere shortening.

Optimal Range: < 3 ulU/mL

C-peptide: Optimal Range: 0.8 to 3.1 ng/mL
Fasting blood sugar: Optimal Range: 75 to 90 mg/dL
Triglycerides: Optimal Range: < 100 mg/dL
HDL: Optimal Range: 59 to 100 mg/dL

Hormone testing: Urine and Saliva
Other Nutrients: Selenium, Mg, Iron, MMA,

Microbiome labs: We look to assess gut health, where around 80 percent of our immune system resides.

Intestinal permeability lab: This blood test looks for antibodies against the proteins that govern your gut lining (occludin and zonulin), as well as bacterial toxins that can cause inflammation throughout the body, called lipopolysaccharides (LPS).

Multiple autoimmune reactivity labs: This array shows us if your immune system is creating antibodies against many different parts of the body, such as the brain, thyroid, gut, and adrenal glands. The labs are not meant to diagnose an autoimmune disease, but to look for possible evidence of abnormal autoimmune-inflammation activity.

Cross reactivity labs: Helpful for people who are gluten-sensitive and who have gone gluten-free and eat a clean diet, but still experience symptoms like digestive problems, fatigue, and neurological symptoms. In these cases, relatively healthy food proteins—such as gluten-free grains, eggs, dairy, chocolate, coffee, soy, and potatoes—may be mistaken by the immune system as gluten, triggering inflammation. To their immune system, it’s as if they have never gone gluten-free.

1. AHCY:

This enzyme is responsible for breaking down the amino methionine by converting S-adenosylhomocysteinase into pro-inflammatory homocysteine. Mood disorders are common for those with a double mutation but typically do well with SAMe supplementation.

2. BHMT:

The BHMT gene directs the enzyme responsible for the amino acid methionine, the building block in the choline oxidation process for optimal brain function. Changes in this gene are associated with ADHD.

3. CBS

No, not the television network! It actually stands for the enzyme that makes the amino acid cystathionine. A mutation of this gene will lead a person to produce more sulfur end products and as a result will need to limit sulfur-rich foods such as legumes and dairy. These foods can increase ammonia levels and contribute to existing health problems. NOS and SUOX are two other genes that can increase sulfur and are linked to immune disorders like asthma.

4. COMT:

This gene is responsible for creating a healthy balance of neurotransmitters and, in turn, a healthy brain. A double COMT gene change is associated with increased risk for anxiety, OCD, bipolar disorder, and ADHD.

5. MAO:

The main role of the MAO gene is to clear out excess neurotransmitters like serotonin. When changes to this gene occur it can create an imbalance in neurotransmitters leading to increased rates of anxiety and depression. Those with an MAO mutation, as well as the MTHFR gene mutation, can have a higher rate of histamine intolerance. Because of this even healthy foods such as fermented foods, bone broth, and vinegar can increase inflammation.


This is not an acronym for a swear word guys, get your mind out of the gutter. The biggest thing I use DNA testing for is to assess methylation, a biochemical superhighway that help your gut, brain, hormones, and detox pathways function properly. This process happens a billion times every single second so if methylation isn’t functioning well, neither are you. Since I often deal with a variety of gut, brain, and hormonal problems in my clinic it is important to see if my patients methylation is working well.

The MTHFR enzyme is responsible for converting folic acid into folate which acts as fuel to the methylation process. A1298C and C677T are the two main MTHFR mutation. When A1298C is altered it can lead to mood disorders due to its important role in neurotransmitter function. C677T changes can cause higher levels of inflammatory homocysteine. Both of these are linked to autism and autoimmune conditions like autoimmune thyroid issues.


These are necessary for B12 production, another methyl donor. Those who have this mutation need higher intake of B12 because their body uses it faster than it produces it. Oftentimes people who have this genetic change can also be low in lithium which is needed for mood regulation. We can easily check lithium levels through testing blood and hair.

8. VDR

VDR stands for vitamin D receptor. Every single cell in your body uses vitamin D. Other than your thyroid hormone, no other nutrient or hormone can claim that importance. It is responsible for over 200 different pathways in the body. Mutations in this gene make it really difficult to absorb vitamin D. It’s important to know if this is the case for you in order to supplement higher doses on a consistent basis to make sure you are getting enough of this vital nutrient.

9. Detox genes

I also look for changes in your detox genes such as CYP1A2, also known as your caffeine gene. This can show just how well you can tolerate caffeine and whether or not it can be harmful or beneficial to your health.

Mar 28, 2019

In Episode 143 of Keto Talk, Jimmy and Dr. Will Cole do a deep dive on the subject of Adaptogens–plant medicines, but not just any old plant medicines– and shine some light on what this means for your health.

"I like to think of adaptogens like Captain Planet. When all the forces combined, they saved the day. Adaptogens are a whole kingdom of substances that all work together, but they all have their own strong suits as well." – Dr. Will Cole

"Most people can find benefit from these adaptogens in their life right now." – Jimmy Moore

What are Adaptogens?

Adaptogens are a broad family of herbs and plant medicines that have been used for thousands of years throughout the world. To be labeled an adaptogen, a plant medicine must fulfill at least three specific criteria:

  • They are generally safe (for just about everyone).
  • They help you handle stress.
  • They work to balance your hormones.

How adaptogens work

Stress and hormone pathways are connected – your body’s stress system, the sympathetic nervous system, controls hundreds of pathways that are responsible for inflammation, and when inflammation gets out of control, this can lead to hormonal problems like adrenal fatigue, low sex drive, and thyroid dysfunction.

Adaptogens help to regulate the sympathetic nervous system so everything downstream works better. And because chronic inflammation is linked to many of the common health problems we see today, the medical literature has found adaptogens to have even more cool and far-reaching health benefits like:

  • lowering cortisol levels
  • regenerating brain cells
  • alleviating depression and anxiety
  • protecting heart health
  • protecting the liver
  • preventing and fighting cancer
  • lowering cholesterol
  • protecting against radiation
  • balancing the immune system
  • decreasing fatigue
  • Adaptogen Superstars

They all mediate stress, fight inflammation, and bring balance to your hormonal system but each adaptogen also has its own special set of skills.

Here are the 12 most popular adaptogens and what you should know about each:

1. Ginseng: The pick-me-up

Ginseng varieties, including Asian White, Asian Red, and American White, are great for those seeking an extra boost of energy without the jitters that can come from caffeine. Personally, I especially like to use it to combat jet lag.

2. Pearl: The beauty secret

Crushed-up pearl powder is a great source of amino acids and will nourish skin, hair, and nails.

3. Rhodiola: The stress calmer

Rhodiola rosea is good for people struggling with adrenal fatigue and fibromyalgia, but it can have a stimulating effect on the extra-sensitive, so take it before noon or it could keep you up at night.

4. Schisandra: The adrenal supporter

Another super adrenal supporter, this berry is one I used on a regular basis during my journey recovering from adrenal fatigue.

5. Shilajit: The sex hormone igniter

People with low libido or sex hormone imbalance can benefit from shilajit. This Ayurvedic herb’s name translates as “conqueror of mountains and destroyer of weakness.” Sounds good to me.

6. Ashwagandha: The thyroid + mood master

A superstar adaptogen, this popular herb is a great tool in supporting optimal thyroid function. If you tend to get mood swings, ashwagandha may also be all the remedy you need. Just watch out – ashwagandha is a nightshade, which may aggravate symptoms (such as joint pain) in some people with autoimmune conditions.

7. Maca: The energizer

Maca both boosts energy and calms anxiety. It’s also a rich source of vitamin C, making it an immunity enhancer. There are three types of maca powders: Red, yellow, and black. Red maca is the sweetest and mildest tasting. Yellow maca is the least sweet, and black maca is somewhere in between the two.

8. Holy Basil (Tulsi): The memory booster

I recommend holy basil to my patients who complain of brain fog because it gently increases cognitive function. As a bonus, it’s also great for bloating and gas.

9. Ho Shou Wu: The libido pumper-upper

Another great tool for people with a low sex drive, this herb has been used for thousands of years in Chinese medicine.

10. Mucuna pruriens: Nature’s chill pill

This adaptogenic bean extract is jam-packed with L-DOPA, the precursor to the neurotransmitter dopamine. I take this daily as it helps with focus and calms me down during my busy day.

11. Eleuthero: The battery pack

If you are dragging through the day, this herb is another great one for optimizing energy levels. Extra stressful week? Eleuthero is your go-to.

12. Adaptogenic mushrooms

Within the adaptogenic kingdom, there is an extra-special group of medicinal mushrooms that offer some of the same hormone-balancing benefits as the adaptogens above and some extra immune-boosting qualities too. These include:

  • Chaga
  • Shiitake
  • Himematsutake
  • Lion’s Mane
  • Turkey Tail
  • Cordyceps
  • Reishi

What are adaptogens anyway?

Adaptogens encompass a wide variety of different natural medicines from all corners of the globe that have a few things in common: They are generally safe and they have a balancing effect on something called the hypothalamic-pituitary-endocrine axis. This is the delicate dance between your brain and hormone system, and include your brain-adrenal (HPA) axis, brain-thyroid (HPT), and brain-gonadal axis (HPG). You need all these communication systems working in perfect harmony for a healthy mood, metabolism, energy, immune system, and sex drive. When your HP axis is unbalanced it leads to hormone problems like adrenal fatigue, thyroid problems, and libido issues. And nobody wants that.

Like the colors of a rainbow or the superhero kids on Captain Planet, the inhabitants of the adaptogenic kingdom sometimes work brilliantly by themselves and sometimes cooperate synergistically with other complementary adaptogens. Usually available in powdered form, you can mix these into your morning coffee, make a caffeine-free tonic, or blend them into your daily smoothie.

The next question is: Which ones do you need? Find your current health issue and I’ll give you a list, but always remember to pay attention to how your body responds to anything new.

Poor complexion, Brittle nails, or Unhealthy hair:

Pearl: This adaptogen of the sea is a great source of amino acids to help nourish hair, skin, and nails.

Chaga: This superfood mushroom is loaded with antioxidants that help fight free radicals to keep skin youthful.

Cordyceps: This is the ultimate anti-aging adaptogen. Not only does this mushroom increase antioxidants, but it decreases the pro-inflammatory monoamine oxidase and lipid peroxidation activity that causes us to age.

Rhaponicum: Full of antioxidants, this root helps to promote cell health, keeping you young and vibrant.

Jiaogulan: Consuming this adaptogen can actually help your body increase its production of superoxidase dismutase. This particular antioxidant protects your body’s cells from premature destruction and aging.


Rhodiola: This herb can help reduce stress and is great for people with adrenal fatigue. However, if you are extra sensitive, be careful because it could potentially keep you up at night.

Mucuna pruriens: This bean extract is packed with L-DOPA, which is the precursor to the neurotransmitter dopamine. I call this nature’s chill pill.

Ashwagandha: Since it has the ability to regulate cortisol, your body’s stress hormone, this is a powerful calming tool to have on hand.

Licorice root: Bring stress down with this cortisol-controlling Zen master.

Hormone Balance:

Schisandra: This berry supports your adrenals and can help fight adrenal fatigue.

Cordyceps: For those struggling with adrenal fatigue, this is a great hormone balancer to help increase energy and stamina.

Ashwagandha: The ultimate cortisol balancer, this helps to support your brain-adrenal (HPA) axis. This herb is also powerful when it comes to thyroid support. Since adaptogens are balancing in nature, ashwagandha in particular is great at boosting sluggish thyroid hormones.

Licorice root: Just like ashwagandha, it helps to heal adrenal fatigue by balancing cortisol levels.


Ginseng: Asian white, American white, Asian red, and Siberian (Eleuthero) all boost energy without the caffeine jitters.

Maca: This herb is available in three different varieties: red, yellow, and black. Red is the sweetest but most mild tasting. Yellow is the least sweet, and black is right in the middle. They are all great energy boosters.

Low Sex Drive:

Shilajit: This herb is used in ayurvedic medicine and translates to “conqueror of mountains and destroyer of weakness.” Shilajit helps to lift up low libido and balance sex hormones.

He shou wu: If sex were an herb, it would be he shou wu. Used for thousands of years in Chinese medicine, this herb helps increase sex drive in those with low libodos. Mix with shilajit for a sexual health tonic.

Brain Fog:

Holy basil (Tulsi): Start incorporating this into your wellness routine if you struggle with brain fog as it works to increase cognitive function.

Lion’s mane: The nerve growth factors (NGFs) found in this mushroom can help regenerate and protect brain tissue.

Rhaponticum: Some studies have shown that this root can stimulate brain activity.


Maca: Packed with vitamin C, this is a perfect immune booster.

Chaga: Studies have shown this mushroom to have powerful antiviral effects as well as immune-balancing properties.

Turkey tail: When consumed daily, it has been shown to improve immune function.

Ashwagandha: This is traditionally used in ayurvedic medicine to help boost the immune system after being sick.

Astragalus: Having strong immune-boosting abilities, this herb has been used to help restore immune function for people with weakened immune systems from cancer treatments or chronic illnesses. In addition, it has powerful antiviral and antibacterial properties.

Anxiety and Depression:

Lion’s mane: Studies have shown that the consumption of lion’s mane can reduce depression and anxiety.

Ashwagandha: Taking ashwagandha has been shown to reduce anxiety by up to 44 percent!

Blood Sugar Balance:

Reishi: This magic mushroom helps to lower blood sugar levels by down-regulating-alpha-glucosidase, the enzyme responsible for breaking down starches into sugars.

Digestive Issues:

Holy basil (Tulsi): This little guy works hard to reduce bloating and gas, for those struggling with gut issues.

Turkey tail: I often give this adaptogenic mushroom to my patients who are battling gut overgrowths like SIBO or candida.

Licorice root: This has been used for years as a common remedy to help heal leaky gut syndrome since it is both soothing and anti-inflammatory.


Shiitake: Japanese studies have shown that this mushroom has the power to actually decrease tumor growth.

Himematsutake: Also known as God’s mushroom, the protein blazein that is found in Himematsutake actually has the ability to kill some cancer cells. Studies have shown that cancer cells died after just a few days of treatment!

Where the heck do I buy these?

You can find many high-quality, organic adaptogens online and at health foods stores. Some of my favorite brains are Moon Juice, Sun Potion, Four Sigmatic, and Real Mushrooms.


Mar 21, 2019

In Episode 142 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Mixed Messages About Bonking On Keto, Yellow And Floating Stool, Idiopathic Thrombocytopenia, Hypoglycemia When Cheating, Traumatic Brain Injury, and more!


  • Response to Dr. William Davis’ column “Is the ketogenic diet dangerous?”
  • What is the ideal ketogenic modality to heal the gut microbiome after food poisoning. No antibiotics were used.
  • Fasting can affect pathogenesis of autoimmune disease but also how to address some of the challenges that patients with autoimmune disease might face if they try fasting, e.g concurrent use of prednisone.
  • What role does keto play in recovering from vaccine injuries?
  • How do I have the proper knowledge about the relevant heart health information with my cardiologist?
  • Why do I get nauseated by eating more fats in my ketogenic diet?

“If you see a number like 29,000 people over 17 years, this is not a randomized, controlled study. That's your clue that this is not good science.” – Jimmy Moore

“You cannot extrapolate from studies of epileptic children that have other health problems and then apply that to the average human being.” – Dr. Will Cole


Jimmy and Will answer your questions:

– Why did I seemingly “bonk” when engaging in demanding skiing conditions while on a ketogenic diet?

Hi Jimmy and Dr. Cole,

I really enjoy your podcast and appreciate your diligent work. My question is about sports performance. I've been doing a lower carb diet for 8 months now, always under 150g carbs and mostly under 100g. For the past 6 weeks, I've been strictly following a keto diet with net carbs under 30, many days around 20g. I'm also limiting my calories and doing intermittent fasting with calories coming in between 1200-1500. Once or twice a week I cycle up to about 2000 calories. I just returned home from a snowboard trip where I experienced a scary problem and I'd like to learn more about the physiology of what may have happened.

The first two days were challenging conditions with a lot of powder. This takes more effort so I'd consider it somewhat demanding exercise, but still aerobic. This was my first trip since going strictly keto and I was still adhering to the diet strictly. On the third day after a breakfast of Canadian bacon and eggs, we got up and headed up the mountain. On my first short run of the day, the trouble began. My legs literally would not work and I had trouble getting up on my board after falling. This happened a few times and I started to worry I may be having a panic attack even though this is not something I've ever experienced on the slopes. I was definitely a little worried about what I was experiencing but I just chalked it up to nerves, calmed myself, and eventually made it down. I assumed resting on the lift would be all I needed.

I got up to the top and the same thing happened although initially I was fine for a few minutes. It was a real challenge to both my legs and my brain and then I started having the same symptoms again about halfway down. These were steep, challenging runs and I began to worry I had just finally freaked myself out to the limit. Then it occurred to me that I may be "bonking"...I've run one marathon and experienced something like that, however, this was very different. I seriously couldn't get my legs to work, as in laying on my back trying to flip over and couldn't even pull my knees up to my chest.

I ended up making it down safely, albeit so ungracefully and very slowly and decided I should probably eat some quick absorbing carbs if I wanted to continue. I slowly ate half of a very large chocolate chip cookie, monitoring how I felt. Incidentally, this didn't even taste good to me and didn't create any cravings in the days after. After a rest, I went back out and was totally back to "normal." I know I'm relatively fat-adapted at this point since I can fast 18 hours easily. However, I've also read it can take months for metabolic processes to fully adapt. I'm guessing what happened is that the demands of the activity outpaced my body's ability to access fat, and being keto, I had fully depleted my glycogen stores. Is that what happened to me? That's pretty simplistic, but I'd love to hear a more detailed scientific explanation of what may have happened.

Thanks again for producing a great show!


– What’s going on with yellow and floating stool when you are eating keto?

Hi Jimmy and Will,

I’m one month and two days in to my new lifestyle, but I still have diarrhea and it’s always yellow.  Is this normal?  Thank you!


Hey Jimmy and Dr. Cole,

I keep a very strict keto diet eating two times a day, so I have a regular bowel movement every other day. But my stool mostly floats. Is this a problem? I consume quality fats and protein with very few carbs in the form of green vegetables. Thanks for your help!


– Does having low platelets and possibly Idiopathic Thrombocytopenia have a connection to eating a ketogenic diet?

Hello you guys,

It looks like my wife is having low platelets and a possible diagnosis of ITP (Idiopathic Thrombocytopenia) and we are working with doctors to find out. We started keto in May 2018 and now consume a meat heavy low-carb, high-fat diet. Is there anything in our keto diet that could cause this or help in the healing process? Would adding in more bone marrow to the diet help?

Thank you,


– How do you prevent bouts of hypoglycemia from happening when you go off plan and consume carbs (other than staying in a state of ketosis)?

Jimmy and Will,

I have been on keto since August and have lost about 50 pounds. I have been testing blood ketones and I am usually at 1.0 mmol+. Over the holidays I had three times when I went out of ketosis and each time I had a bad reaction. About 2-4 hours after consuming carbohydrates, I would have what I think is a hypoglycemic reaction with terrible nausea, diarrhea, sweating, and shaking. I was unable to test my blood to see what my glucose reading was because I felt so bad. After a few hours of resting I would start feeling normal again and eating carbohydrates after that was fine. But each of the three times I was getting out of ketosis I had this reaction. Any thoughts on why this is happening or ways to prevent it (besides the obvious of just staying in ketosis)?  One more bit of info, the third time it happened I was trying to prevent it and instead of eating a big meal I kept snacking to try and keep my blood sugar up and that didn't work. Thanks for all your help and I hope to hear your response.



– What are the mechanisms behind why a ketogenic diet and periods of fasting help with traumatic brain injury?

Hello Jimmy and Will,

Thank you for your work. It is a pleasure to listen to Keto Talk. I have an observation about high-fat/low-carb that you and other listeners may find interesting. I sustained a very bad sports concussion in 2011 and this injury knocked me out (literally!) of school, all physical activity, and nearly all social interaction for upwards of six months. Most of my symptoms subsided within a year, but I had several longer-lasting cognitive effects, including math and language impairment, lack of focus, and increased irritability. One of the more prominent personality changes I noticed after the concussion was the sudden development of OCD, especially compulsion, and heightened anxiety and paranoia. In the years since, I have learned to live with this and work around my "new self." I have even been to counseling, which was somewhat helpful. When I first became concussed, my medical team recommended I take omega-3 fats in the form of flaxseed oil supplements, as well as an anti-seizure medication.

This past summer, I adopted a Paleo diet which quickly transitioned to Paleo ketogenic and I recently began implementing periods of fasting. I am doing all of this for health/longevity/vanity benefits, unrelated to my concussion. Since introducing fasting to my ketogenic diet, I am becoming my "old self" again. I have experienced all the benefits of ketosis and fasting—mental clarity, emotional stability, physical changes, physical performance PR’s, and more. But I never expected that the effects of my concussion would be reversed. They are not gone completely, but every fasting cycle I see huge improvements.

After doing a quick search of Dr. Google and looking on PubMed, I found out that this is a thing. People are using ketosis and fasting to heal traumatic brain injury. And it makes perfect sense- the neuroprotective aspects of fasting and a ketogenic diet should theoretically also help heal. Can you talk more about the mechanism of this on your podcast? My concussion was relatively minor, but there are people with CTE and servicemen coming back from overseas with PTSD and very serious traumatic brain injuries. This could be life-changing for so many people.

Again, thank you for what you do! You are so gracious on your show, and I so appreciate your continued dedication.



Mar 14, 2019

In Episode 141 of Keto Talk, Jimmy and special guest cohost Dr. Jay Wiles from  answer your questions about Mixed Messages About Keto, Hypopituitarism, Convincing Skeptics Saturated Fat Is Healthy, Insulin Pump And Ketosis, Type 1 Diabetic Weight Gain On Keto, and more!


  • Dr. Wiles shares about the intricate role that a low-carb, high-fat, ketogenic diet can play on overall brain health, cognitive performance, and overall psychological well-being.
  • Can a ketogenic diet help with ocular migraines?
  • Does eating keto improve the headaches that are associated with a brain colloid cyst?
  • Why does eating keto and fasting have such a calming effect on your mood and mental health?
  • Is there a period of keto-adaptation necessary to see an improvement in an EEG for persistent sleepiness?
  • Will a ketogenic diet be dangerous for someone with chronic anxiety and a general eating disorder?

“Nobody ever asks if the SAD diet that people have eaten for years is the cause of diabetes, but they jump at the chance to blame keto.” – Jimmy Moore

“With a ketogenic diet we can significantly reduce the occurrence and severity of migraines.” – Dr. Jay Wiles


Low-Carb Diets Linked to Higher Odds for A-Fib

NIH Study Probes Impact of Heavy Screen Time on Young Brain

Diet for Alzheimer's: Waikato trial to pit ketogenic and healthy diets against the disorder

– STUDY: New study links Alzheimer's disease with liver function and diet

Jimmy and Jay answer your questions:

– What can I do to prevent the sore, dry eyes that came on when I switched over to keto to help with chronic daily headaches?

Hi Jimmy and Jay,

I went into ketosis for a few months before Christmas with the hope that it might help me with chronic daily headaches I have had for many years. It really helped and I'm hoping it can be the cure I’ve been seeking for so long. However, there were a some side effects which I wonder if you could help with like sore, dry eyes which feels like I’ve drank too much alcohol. What’s going on with this? Liver issues? Dehydration? Lack of sleep? When I switched back over to a “normal” diet during Christmas, my eyes got a lot better.

Since the beginning of the year I’ve cut my carbs again (but not fully keto) and the eye pain is back again. I’ve tried supplementing daily with magnesium, potassium, fish oil, a multivitamin, 5-HTP, a probiotic, and butterbur (which is supposed to be good for headaches). I also put pink Himalayan sea salt in my water and drink 3 liters of water daily. Any help you can give for this issue would be greatly appreciated.

Keep up the good work!


– Will keto help normalize my DHEA-S levels as my blood sugar and insulin levels come down into the healthy range from eating keto?

Hello Jimmy and Dr. Wiles,

I’m a female in my early 40s with elevated DHEA-S coming in at 509. My endocrinologist did additional testing to rule out congenital adrenal hyperplasia and nothing came up. I also have elevated postprandial blood sugar due to metabolic syndrome which also comes with extra weight around my midsection. My question for you guys is this—could my glucose/insulin issues be the reason why my DHEA-S has increased? Or is it vice versa? And will keto help bring this level into normality? I’ve been doing keto for several months and have lost almost all the extra weight around my middle, but I’d love to know more about this DHEA thing.

Thanks for your help,


– Can a low-carb ketogenic diet help bring about healing for the symptoms of someone who has experienced strokes in the past?

Hi Jimmy and Jay,

I love Keto Talk and find it so helpful! I have been looking for information on stroke and keto but have not find anything yet. My boyfriend had a couple of strokes many years ago and now suffers from brain fog, chronic pain, and other quality of life issues. I have been eating keto for a couple of months and have seen so many great benefits. I can't help but think my boyfriend would benefit from doing it as well. Is this wise?

Thank you for answering my question,


– Is my elevated prolactin levels a result of my low-carb, high-fat, ketogenic diet?

Hey Jimmy and Dr. Wiles,

Thank you for playing such a strong part in my journey to better health. In January 2014, I weighed in at 285 pounds and lost 50 pounds with juicing. After slowly gaining back all the weight after getting frustrated with doing that, I then got diagnosed as prediabetic in June 2016 and it terrified me since my older brother has Type 2 diabetes. Fortunately I found the work of Tim Ferriss which led to me the cyclical ketogenic diet and then into full-time keto which helped me lose over 100 pounds. So far so good, right?

I recently went to the doctor and got some bad news about my prolactin levels indicative of the health of my pituitary gland. Normal range is 2.1-17.7, but mine came in at 63.9! Is this increase in prolactin a result of eating keto or is it something completely unrelated to my diet? My doctor is going to run an MRI to see if he can find out more about it. Is this normal for ketosis?

Thank you in advance,



– Is developing vertigo a common problem with switching over to a ketogenic diet? What is added or subtracted from the diet that would cause this?

Hi Jimmy and Jay,

After doing keto for a little while now, I’ve just experienced vertigo for the very first time. Is this a common side effect of keto? Does it mean I’m getting too much or too little of something in my diet now that would cause this? I’d appreciate your help in understanding this.


Mar 7, 2019

In Episode 140 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Mixed Messages About Keto, Hypopituitarism, Convincing Skeptics Saturated Fat Is Healthy, Insulin Pump And Ketosis, Type 1 Diabetic Weight Gain On Keto, and more!


  • Will’s Functional Medicine perspective on Jimmy Moore’s upcoming 6-month sabbatical (what to expect, the mental challenge, health changes that should happen, and acclimating to the work load again when he returns)
  • Is cutting back on fat the first change to make when weight loss isn’t happening on keto?
  • What are the effects of long-term ketosis on female reproductive hormones, specifically estrogen production?
  • Since the liver needs glucose to convert T4 to T3, does this mean keto leads women especially to develop hypothyroid unless they eat some whole food carbohydrates?
  • How can I deal with the continued hormonal headaches that are reduced but not completely eliminated with keto?
  • Is it true that there may be some health concerns associated with consuming cooked fats (i.e. makes them more carcinogenic).

“As a rule I don't use avocado or olive oil for cooking because butter, coconut oil, lard, and all these stable saturated fats do such a great job for cooking.” – Jimmy Moore

“I think being proactive and addressing health issues before they become serious is a brave move and one that is a counter cultural idea.” – Dr. Will Cole


Jimmy and Will answer your questions:

– Are concerns over lack of nutrients and acidity in the body on keto valid? How can you cut through the confusing mixed messages on keto?

Hello guys,

I am incredibly frustrated with my keto experience so far and hoping you can help. I am a 5'3" female and weigh 155 pounds. I started this journey to help me with brain fog, afternoon slumps, and energy level issues and I finally started to feel better after a really rough two months trying to get keto-adapted. While I have gotten better now, it seems to be a bumpy ride so far.  As a runner I’m seeing a negative impact on my endurance, my menstrual cycles have become very intense, and I’ve experience zero weight loss (although that’s not a goal, it would be nice to see). I’ve been doing a ton of research and listening to podcasts trying to figure out if I’m doing something wrong and perhaps seeing if getting the benefits of keto is any different for women as compared with men. I hear things about keto causing acidity in the body which is the precursor to the development of disease and it kinda freaks me out. My diet is very rigid most of the time eating mostly organic foods,  very little red meat, and focused on fish, chicken, turkey, and more vegetables thanks to reading Ketotarian and Dr. Anna Cabeca’s new book. I’m ready to give up on my keto plan because of the lack of nutrients and acidity concerns. There seems to be so many mixed messages about keto that I don’t know what to believe and how to do it the right way for me. My desire is to be healthy, not skinny. Can you help me out?

Thank you for answering my question,


– Why would ketones not show up in blood testing from two years of eating very low-carb? Does it have to do with hypopituitarism and will keto perhaps help with this?

Hi Jimmy and Dr. Cole,

I’m a huge fan of Keto Talk and I learn something new every time I listen! I have been eating real food keto staying under 20g of carbs daily for the past two years but have never registered more than .02 on my blood ketone meter. Is this normal for someone who has hypopituitarism? Can eating low-carb, high-fat, ketogenic help with this?

Thanks again for all you do,


– How do you convince friends who think saturated fat and cholesterol are leading to heart disease on keto? Are there third party resources that can explain all of this?

Hey Jimmy and Will,

Saturated fat and cholesterol are the primary concerns that my vegan and vegetarian (and even my SAD dieter) friends point to when it comes to the keto diet. Even when I point out that plant-based food sources such as coconut and olive oil both have more saturated fat than most animal-based foods, they argue that this way of eating will raise cholesterol and saturated fat levels in the blood which will inevitably lead to atherosclerosis and heart disease. I’ve asked them to read your book Cholesterol Clarity, Jimmy, but my very intelligent and mostly skeptical friends want resources from “unbiased” sources since you are a prominent figure in the keto space. I really need some third party resources to share with them about the healthy role of saturated fat, cholesterol, and why a ketogenic diet is a positive thing for the body. I’m shared about Nina Teicholz’s book The Big Fat Surprise as well as the Joe Rogan podcast debate between vegan Dr. Joel Kahn and Paleo diet practitioner Chris Kresser. Do you have other suggestions?

Thanks for your help!


– Does being a Type 1 diabetic using an insulin pump make it that much more difficult to get into a state of nutritional ketosis?

Hello Jimmy and Dr. Cole,

I am a Type 1 diabetic since before I was 2 years old and I’m on an insulin pump as well as dealing with juvenile rheumatoid arthritis, Hashimoto’s thyroid, and celiac. I eat low-carb keto and my blood sugars stay in tight control. My thyroid levels are very good thanks to the Nature-throid medication I use. But here’s my problem—I can never get into a state of nutritional ketosis. Is it because I’m on an insulin pump and there is a constant flow of basal insulin being injected into my body? Over the years, I know I've become insulin resistant and have gained weight especially in my midsection. I'm 47 years old and ever tried working with a personal trainer for two years…but all I did was gain more weight in my belly. Why is my body holding onto fat and not burning it when I’m eating keto?

Thank you for helping me with this puzzle,



– Why would a Type 1 diabetic getting good ketone levels struggling with weight loss unless calories are significantly reduced?

Hello Jimmy and Dr. Cole,

I'm 54 years old, 5’2”, and 143 pounds, and needing to lose just a few more pounds. I currently have 25% body fat and lift weights regularly. I've been a lot like you, Jimmy, trying all different kinds of diets and reducing calories—but nothing seemingly works! I know I got too hypocaloric at one point and increased my calories again. I’m a Type 1 diabetic on an insulin pump and don’t need very much insulin because I keep carbs below 20g, 70-80g protein, and fats from eggs, avocados, butter, cheese, and fatty meats. My blood ketones are in the healthy range of 0.7-1.9. As much as I believe in keto, I can’t deal with gaining weight. The only time I’ve seen the scale move is when I’ve cut calories to 1100 a day. But I know that’s not a healthy level for me to be consuming long-term. Why is this so hard for me? It feels like all of the low-calorie, low-fat diets I’ve always suffered with. I really thought keto was different from those.

Please help me figure this out.



Feb 28, 2019

In Episode 139 of Keto Talk, Jimmy and special guest co-host Dr. Gus Vickery answer your questions about Loose Stools From Higher Fat, Diabetic Neuropathy, Antibiotics While Fasting, San Filippo Syndrome, Regular Exercise On Keto and more!

We begin today's show with special guest co-host Dr. Gus Vickery from talking about Dr. Vickery's basic philosophy on nutrition and health, and his unique seasonal use of fasting and ketosis with patients as a way of honoring ancestral design.


1. There’s a weight loss medication called CONTRAVE I’d like to use to help control carb cravings while I am adapting to keto. Is this a good idea?
2. When I try to stop taking the prescription version of Prilosec that I’ve taken for 15 years after starting keto, my heartburn is as bad as ever. Will keto help heal this?
3. What is the best way to eat a healthy ketogenic diet on a tight budget?

“There are times that we blow by satiety because the keto foods we eat taste so good, but if you listen carefully to your satiety signals you can get that dialed in.” – Jimmy Moore

“It's not normal for children to be diagnosed with metabolic syndrome and the number one cause is the change in our eating patterns.” – Dr. Gus Vickery


Jimmy and Will answer your questions:

- What’s the solution to dealing with loose stools stemming from eating more calories and fat-based keto foods that normal?

Hi Jimmy and Dr. Vickery,

I’m a big fan of Keto Talk and I’ve listened to every episode since day one. I’ve been eating keto for the past four years and love this lifestyle. I’ve been constantly tweaking and refining what I’m doing to dial in the amount of food and macronutrient ratios that help me feel the best. So far so good.

But I will admit there are times on occasion that I overindulge in the amount of keto foods that I consume that puts more calories and especially fat into my body than my body would typically require. I can always tell when I’ve done this because I have very loose stools. I’ve listened to your show enough to know that is likely a result of eating more fat than I need or some gut health component.

The obvious solution is to stop doing that, but I’m wondering if there is anything I can do before, during, or after those times I have a bit more than normal to mitigate these side effects in my bowels. Thanks so much for your answer and keep up the great work!

Brian in Winnipeg, Manitoba, Canada

– Does diabetic neuropathy ever get fully healed once blood sugar becomes stabilized from eating a ketogenic diet?

Hi Jimmy and Gus,

I have type 2 diabetes as a 51-year old male, 6’3”, 255 pounds (down from 326 pounds since starting keto seven months ago. My A1C has dropped from 7.8 to 5.2 and I came off all my diabetes medications four months ago. The only remaining physical effect I’m dealing with from my pre-keto days is a a slight neuropathy in my feet. Will this ever improve completely or is the nerve damage just too severe for even keto to help heal? Thanks for all you help on this journey because your show has been a real inspiration.


– Does taking an antibiotic cause the body to respond adversely during extended fasting?

Hey Jimmy and Dr. Vickery,

Thank you for being a sounding board for all things keto and fasting! It has truly inspired me in my own journey. I have been eating keto since the beginning of the new year and I’ve noticed this way of eating makes fasting for upwards of 24 hours very easy to do. I tried my first 72-hour fast this week to see how I’d do and the first 24 hours was a cinch. Day two was a challenge, but I already knew that from hearing Jimmy talk about this so much. I was anticipating the “euphoria” of day three, but at hour 58 I woke up feeling absolutely horrible. I took some salt, drank coffee, pounded water, and did my best just to walk on the treadmill for a mile that day. After the workout I felt so bad that I knew it was time to end the fast because hunger pangs and food cravings at that point were just too much to bear.

I feel like I did everything right and saw blood ketones in the 2.0-3.5 range and blood sugar in the sixties feeling great. There is one monkey wrench in this story I haven’t shared yet, but on the night of day two of this 72-hour fast, I had to take an antibiotic. Is it possible that is the culprit in my hunger and symptoms that forced me to quit the fast? Is there a way to safely and effectively get the benefits of fasting if you are taking an antibiotic? Thanks for all of your guidance and support for the keto and fasting community!


– Would a ketogenic diet with periods of intermittent fasting perhaps help children who are afflicted with San Filippo Syndrome?

Hey guys,

I saw a story on the news last night about kids who get Alzheimer's-like symptoms and, dementia at the age of two and then go downhill fast living as long as five years. When I looked up this condition called San Fillipo Syndrome, it seems these kids have trouble breaking down sugar and clearing cellular trash. Do you know if this condition is being researched for the impact a ketogenic diet could play on it? Like epilepsy, perhaps a simple diet change and maybe some intermittent fasting may be all that's needed here. What role would the diet of the mother during pregnancy play in preventing a condition like San Fillipo Syndrome from developing? Thanks for your thoughts on this.

This Old Housewife


– What impact does engaging in regular exercise while eating keto have on cholesterol and general health?

Hello Jimmy and Gus,

I listen to Keto Talk frequently when I am working out at the gym. My story is quite unique as I once weighed in at 799 pounds at the age of 16. With lots of prayer and commitment to my own health, I was able to lose around 600 of those pounds. Today, I am a very active person and have been eating low-carb for the past nine years. In late 2018, I decided to shift my nutritional intake over to the ketogenic diet. I love to move and do an hour plus of cardio six days a week as well as strength training for 20 minutes 3-4 times per week. I have a standing desk at work, and I attempt to move as much as I can throughout the day - sometimes even doubling up on the cardio sessions!

My question for you guys is this: What impact does all this exercise that I do have on my cholesterol levels while eating a ketogenic diet? How well does engaging in regular exercise like I do pair with keto? Do you recommend that people eating low-carb, high-fat engage in some form of cardio to ensure proper heart health and weight management? Thanks for your help with my questions.




– Listen to Dr. Gus Vickery on Episode 1469 of The Livin’ La Vida Low-Carb Show

Feb 21, 2019

In Episode 138 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Arteriosclerosis Reversal, Acetyl-CoA, Gastro Event Requiring Antibiotics And Pasta, Fasting And Appendicitis, Keto Aggravating Adrenals and more!


  •  Why is cheating on your keto diet everyone once in a while a bad thing?
  •  What do you think about the new sweetener allulose being used in keto products?
  • Does using collagen, bone broth, and MCT oil break your fast and turn off autophagy? 
  • Could the carrageenan typically found in heavy cream be the cause of my skin issues?
  • Does having chronic pancreatitis requiring prescription pancreatic enzymes preclude someone from eating keto?

“Buyer beware when it comes to some of these food substitutes on the market.” – Jimmy Moore

“It's not fair that some of us can tolerate certain foods while others can't, but we have to accept where we are on our health journey at this moment.” – Dr. Will Cole


Jimmy and Will answer your questions:

–  Is there any research showing reversal of arteriosclerosis with keto and other lifestyle changes?

 Hi Jimmy and Will,

 I’m a big fan of the ketogenic diet and you guys consistently provide some of the best information about this way of eating online. I’ve been doing a lot of research lately on how to reverse arteriosclerosis since it seems most people have some varying level of this develop during their lifetime. I've seen people talk about things like taking magnesium and the MK7 variant of Vitamin K2, but these are only theoretical in nature. Is there any scientific evidence that this actually reverses the progression of heart disease? Is there any research that demonstrates keto and other lifestyle approaches help with this reversal of arteriosclerosis? Thanks again for your fantastic podcast.


– Is there any concern with an increased production of Acetyl-CoA when a Type 2 diabetic is eating keto?

 Hey guys,

 I have someone in my life who has a biochemistry background claiming that going keto is about the worst thing a person with Type 2 diabetes could possibly do because of excessive production of Acetyl-CoA and that it induces a state of ketoacidosis (which I know is flat-out wrong). When I inquired about the mechanism about how the higher Acetyle-CoA issue happens and what the end result would be from this, she responded with something about DNA damage being done on a neurological level. This doesn’t make any sense to me from what I know about healthy nutritional ketosis and I’d love to offer up a counterpoint to her arguments. She seems to be really confused and it would be great to help educate her on this. Thanks for your help!



– What is the best way to recover my gut health from three rounds of strong antibiotics?

 Hello Jimmy and Dr. Cole,

 I recently had a gastro event that my gastroenterologist put me on two strong antibiotics (Cipro and Flagyl) for. As a keto dieter, I was shocked when he recommended that I eat lots of pasta before having a colonoscopy. When I told him I eat for ketosis, he chided me by staying that diet is merely political and not actually based on any sound science. I’m almost sure I have leaky gut and declined having the colonoscopy since the antibiotics have surely almost entirely wiped out my gut flora. I’m now eating the Specific Carbohydrate Diet (SCD) and am doing well on it so far. I did have to take another antibiotic (Methylpred) for a pulled tooth recently, so I know my gut health is majorly compromised now. Is there anything else I can do to help further improve my gut health so I don’t have to go through these rounds of antibiotics and recommendations of pasta anytime soon? This has been a very hard winter for me. Thank you for responding to my questions.


 – Does extended fasting lead to appendicitis and gallstone development?

 Hey Jimmy and Will,

 I was inspired to start doing some longer fasting because of your podcasts and decided to do a 7-day fast. It was surprisingly easy for me to do and I felt great after it was finished. But one week after I finished that 7-day fast, I developed appendicitis. Was this somehow related to the fast or is this merely a coincidence? Checking Dr. Google didn’t help me answer this question at all which is why I’m writing to you today. They did find I had a developed a a gallstone which Dr. Valter Longo has said can happen on fasting. I’d love to go back to my regular 24-36 hour fasts, but now I’m scared because I don’t want to lose my gallbladder. Can you help reassure me about this issue?

 Thank you and best regards,

Andy in the Philippines



 – Is keto making my adrenal issues worse?

 Hi Jimmy and Will,

 Thank you for all you do on Keto Talk to get sound information about healthy eating out to the public. I’ve been keto for just over a year and have lost 32 pounds while improving many of the symptoms of insulin resistance. I’ve felt energetic for my active lifestyle of mountain biking, running, cross country skiing, and snowshoeing. However, lately I’ve been having a few episodes of what I suspect may be symptoms of adrenal insufficiency. I have dealt with low thyroid and my naturopath put me on thyroid hormone replacement to deal with this—but it didn’t help or hinder. The focus of my treatment has been on healing the gut microbiome and I’ve been consuming copious amounts of bone broth and fermented food like yogurt to help with that along with periods of intermittent fasting. 

 I recently dealt with a virus that wouldn’t let go leaving me pretty sick and worn out for about two weeks. When I started feeling better, I noticed my lymph nodes in my neck were noticeably swollen and tender to the touch. At night, the back of my legs were achy near the back side of my knees. Waking up in the morning felt like I was hungover with my eyes swollen, a low-grade headache, nausea, and incredibly lethargic. When my chiropractor touch my T12 on my back, I felt a hot stinging sensation and immediately because nauseous. She told me that is directly tied to the adrenals. Is keto making these adrenal issues worse? From what I’ve seen, the recommendation for adrenal problems is to eat more carbs, but I don’t want to do that for a lot of reasons. 

 Thank you for helping me try to figure this out. 



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Feb 14, 2019

Today on Keto Talk, Dr. Will Cole shows us some examples of real-world patient cases that have been treated with functional medicine in episode 137.

Highlight Quote:

“My heart and passion is getting to the root cause of what's causing people to struggle, using functional medicine in a ketogenic context.”

-Dr. Will Cole
We talk a lot about health and healing through the prism of a real food ketogenic approach and looking at wellness from a Functional Medicine standpoint here on Keto Talk. Dr. Will Cole from is a practicing Functional Medicine Practitioner and brings us a special treat today as he gives us a look at some real world examples of conditions he has helped treat at his clinic using this unique approach. Here are some of the topics Jimmy and Will discussed in the patient examples in episode 137:

– Lyme / Viral major components

Face and lips swell any time she has an exposure to food she shouldn’t.
Dramatic increase of symptoms with exposures
Falls asleep at table eating/ Extreme fatigue.
– Alopecia

Hair growth after 4 months. Hair, eyelashes and eyebrows
Significant weight loss.
Significant anxiety decrease
– SIBO/ Stomach distention

Within one week up to 95 % of symptoms has resolved
First time her stomach has been flat in 4 + years.
Mood stabilized.
Major factors in case: stress and diet.
– Autistic

Improvements with interaction with parents
Improvements in mood
Trying to communicate
Mood stabilizing.
– Diabetic/ Mold exposure

Mold numbers consistently low.
Had remediation of kitchen and c3a has improved.
– Dizziness, autoimmunity , blurry vision (parasites)

Since dietary changes / improved vision / symptoms 60% resolved
Highlight Quote:

“When you get the hyper reactivity to mold, it's nothing to play with.”

– Jimmy Moore

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Feb 7, 2019

In Episode 136 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about ‘Dead Foods’ Thinking With Cooked Meat, Gut pH, Melasma And Sjögren’s Syndrome, Triglyceride Spike On Keto, Stage 3 Kidney Disease, Constipation and more!


World Cancer Research Fund recommendations on a healthy cancer preventing diet and their philosophy on eating red meat
Can you eat keto without having very much saturated fat because of an APOE4 genotype?
Are there special considerations with keto for people who have had their thyroid completely removed?
Why would Vitamin A levels skyrocket on keto and can there be a toxic elevation of it to be concerned about?
What’s the mechanism that would cause weight gain when people start eating low-carb, moderate protein, high-fat?
Why do nutritionists think a ketogenic diet will crash your adrenals and what could be done to prevent this?
“People that go keto need to be aware that their medicines might need to be adjusted.” – Jimmy Moore
“We know the brain benefits of the ketogenic diet. I would advocate people that are at risk of Alzheimer's disease to eat a whole food keto diet.” – Dr. Will Cole

What are the long-term effects of a ketogenic diet?
Not all carbs are bad: Study shows high-carb diets can promote healthy brain aging
Skinny genes the 'secret to staying slim'
Trans Fats: Going, Going…Gone : COMMENTS ON THIS ARTICLE FROM LISTENER KATE:Everything was great until I got to the last paragraph:"While most vegetable oils are good substitutes [for transfats], tropical oils such as palm and coconut oil are high in saturated fat, and their effects on the heart are still unclear. There are also environmental concerns with palm oil: Increased demand has led to large-scale deforestation and animal habitat destruction in Indonesia and Malaysia as land is cleared for new palm plantations. All of this is just more reason to eat whole unprocessed foods, which are naturally free of artificial trans fats.”Seriously, are we now supposed to make food determinations based on “unclear effects” on the heart? and whether is harms the environment? Well then, I believe everything in the grocery store should be examined for these two things. Nothing would be left except products from local farms. And since when are vegetable oils considered "whole unprocessed foods”?I thought Berkeley Wellness was a pretty trustworthy publication - but this just shows me they are like any other tabloid magazine.
Getting yeast to make artificial sweets
STUDY: Diabetes type 2 warning - the one weight loss diet plan that could cause high blood sugar
Jimmy and Will answer your questions:

– How can a former raw vegan feel more confident about eating cooked meats when the mentality is these are dead foods compared with vegetables being life-promoting?

Hey guys!

I love this podcast and I’ve been keto for more than two years. One thing I still struggle with is feeling like I don't get enough veggies in my diet. I used to be mostly raw vegan and still think of plants as living foods that provide living properties like antioxidants that heal the body. Sometimes I feel torn between wanting to make veggie juices or green smoothies instead of cooked meats and other animal-based keto foods because I always thought of them as dead foods. The ironic thing is I know I feel best in ketosis with more energy, stable mood, and no joint pain. Should I be concerned about having these thoughts? Is it really okay to be consuming cooked meats and smaller amounts of non-starchy vegetables? I guess I’m looking for confirmation that this is enough nutrition to build healthy cells. Please help ease my mind.

– What is necessary for properly balancing the gut pH levels when you eat keto?

Hi Jimmy and Will,

I have read your books and am fully dedicated to the keto lifestyle. I was wondering if you guys could share your thoughts on how to stay properly balanced with your gut pH (alkaline vs. acid) while pursuing ketosis. It’s seems adding in a small amount of grains along with the non-starchy vegetables you consume on keto would be enough to balance this. Does this make sense or do you have another perspective on this that I’m not yet understanding. Any help on this would be greatly appreciated.

– Will autoimmune issues like melasma and Sjögren’s syndrome ever fully heal with a ketogenic nutritional approach?

Hello Jimmy and Dr. Cole,

I’m a 40-year old female who has been battling autoimmune disease (Sjögren’s syndrome) for more than 10 years and I’ve made great strides. I started to get melasma when I was 30 years old and I’m convinced that this is from my hormones going haywire. I am no longer taking plaquenil for pain and inflammation since going keto three months ago and I haven’t felt this good in years. But I really hate the melasma and want to see my body fully heal from this and my autoimmune disease. Will this eventually start showing signs of healing if I stay in nutritional ketosis? Anything else I can do along with keto to spur this on?

– Why would triglycerides spike early on eating keto? Will keto help stage 3 kidney disease?

Hi Jimmy and Will,

I started keto three weeks ago and recently had some blood work done that shocked me. I had a huge spike in triglycerides—up to 700! I have had traditionally high triglycerides 150-200 for years. I’ve increased my fat intake and consumed very low carbs (< 30 grams), yet it scared me to see this large jump in triglycerides. It is noteworthy that I am recently diagnosed with Type 2 diabetes and have stage 3 kidney disease. I also recently stopped my statin and beta blocker medications. So my questions for you guys is this:

1. Why did I see a spike in my triglycerides to 700 just three weeks into the diet ?
2. Is a ketogenic diet suitable for someone with stage 3 kidney disease?

I have listened to nearly all of your Keto Talk episodes going back to the very beginning. It’s always found this podcast so interesting and I love the great answers and information.


– Why is constipation a problem early on when I switched over from a Paleo diet to keto?

Hi Jimmy and Will,

I came to keto a couple of days ago from a Paleo diet and I used to have a very active bowel system, especially in the morning. I’ve never experienced constipation in my life, but I’ve gotten it eating keto and it’s showing up as a bloated belly. I’m struggling keeps my carbs low and protein moderated while all these fats on keto have made me nauseous and I’m hungry. What am I doing wrong? I drink a LOT of water, including bone broth and magnesium at night. I’m also eating spinach, chia seeds, and castor oil to try to get things moving. Do I need psyllium husks or digestive enzymes?

Thank you for your help!


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Jan 31, 2019

In Episode 135 of Keto Talk, Jimmy and Dr. Will Cole answer your questions about Age Considerations With Keto, Unexpected Weight Gain, Long QT, Intense Nausea, And Retaining Breast Enhancement Fat While Keto and more!


With the popularity of keto at an all-time high, it seems strange that the food companies keep pumping out new incarnations of crappy carbage
How can you get a Freestyle Libre flash blood glucose monitor prescribed by a physician without being diagnosed as a Type 2 diabetic?
Can going keto be a part of the healing process from Grave’s Disease?
What role does keto specifically play in helping to “blow out the SIBO” as Will as described it on a previous episode?
Why would skin get more sensitive and even develop eczema once you get keto-adapted?
What role does a low-carb, high-fat, ketogenic lifestyle play in dealing with the inflammatory condition known as hyperhomocystinemia?

Finnish Doctor Persecuted For His Book: A Life Without Drugs
Keto diet: High in fat and popularity, but is it healthy and sustainable?
Inside the Rise of Keto: How an Extreme Diet Went Mainstream
12 Keto-Friendly Foods That Aren't As Low-Carb As You Think
The keto diet was accidentally discovered in 1862 by a funeral director who lost 52 pounds on a diet of cordial and meat
STUDY: Fasting Appears to Reset "Crucial" Clock on Aging-Related Diseases  – DIRECT LINK TO PAPER: Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle
Jimmy and Will answer your questions:

- Are there age and gender specific considerations with keto to be aware of?

Hi Jimmy and Will,

Several months ago my elder sisters (71 and 72 years old) started keto after seeing how well it worked for me (I'm quite a bit younger at 57). They're well on their way to their weight loss goals but they've recently noticed there might be some age-related and gender-related considerations for women who are 70+ years of age. Would you guys talk about some of these things they should be thinking about? Thank you!

– What can be done about unexpected weight gain while in nutritional ketosis? Are my hypothyroid and pain medications making things more challenging for me?

Dear Jimmy and Dr. Cole,

I listen regularly to Keto Talk and I'm grateful for all of your valuable information. I’m 5’6” tall and weigh 179 pounds as a 61 years old woman and have been keto for a couple of years. I started eating this way when my family doctor suggested I may be pre-diabetic with a fasting blood glucose of 101. My blood ketones remain in the 1.5-2.0 range, so I know I’m burning fat. Initially I lose 55 pounds, but for some strange reason I gained back 10 pounds. Although I have a function medicine medical doctor, she’s no fan of me trying longer fasts because of my hypothyroid issues which I take Armour thyroid for.

I’ve tried changing things up in the way I’m doing keto, including a protein sparing modified fast with significantly less fat than I typically eat and carnivore. These did help me lose some weight, but both gave me problems and the weight I lost came right back on with my regular keto diet. I am currently preparing for a women's mini-triathlon (1.5 mile kayak, 11-mile bike, and 3.1 mile walk or run) which takes place in February. I did this last year in a fasted state and did great! I feel like that's not going to be the case this time around. I'd like to at least remain keto but I’m thinking being mostly carnivore is where I feel my best. I will add that my doctor prescribed me Gabapentin 100mg for me to take at night to help with pain that interferes with my sleep. Do I need to add in additional carbs to what I’m doing to help with these issues or should I be concerned?


– Are there any specific alterations to keto for people dealign with the condition known as Long QT?

Hi Jimmy and Dr. Cole,

I am a huge fan of your podcast and listened to all of them in double time so I could digest all the information faster (I especially liked the Poopcast and now I refer to Will as Dr. Pooptacular!). In the earlier episodes I was listening to, Dr. Nally mentioned that Long QT is a reason to be monitored by your doctor when starting keto. This piqued my interest since I deal with this condition. I have an implanted heart monitor that checks for abnormal rhythms 24/7, so I’m assuming that would catch any issues. Are there any specific precautions I should be taking with long QT and keto (mine is the incredibly rare genetic variant, Long QT type 10, which has to do with a sodium channel pathway and is most similar to Type 3 of the more commonly known types).

Signed, your healthiest chronically ill Ketonian,

– How can someone overcome intense nausea while on a ketogenic diet?

Hi Jimmy and Will,

I am a naturopath in Australia and I have been keto for a few months. I had a fairly easy adaptation but my partner is now having a lot of nausea. He started a couple of weeks ago and got into ketosis in about 48 hours with blood ketones around 1.2. He was doing so well until I made the mistake of giving him some cake I had made with almond and coconut flour. He almost immediately started feeling sluggish and experienced mental fatigue and fogginess as his blood ketones crash to under 0.5. He was able to get back into ketosis again, but the nausea and other side effects have been relentless ever since. We’ve been adding in more salt to try to help, but nothing is helping so far. I feel like I broke the momentum he had on his keto and would love any suggestions about how to help him get back on track again. He came to keto from a mostly fruit-based diet for a year prior to this. I feel my partner has so much to gain from eating this way coming from a history of chronic fatigue!

Thanks for your help,


–  Are there concerns with the inability to retain transferred breast enhancement fat for someone who is eating a ketogenic diet?

Hello Jimmy and Dr. Cole,

I am looking to have liposuction to transfer the fat to my breasts for a natural breast enhancement after going through breastfeeding and experiencing a nice weight loss thanks to keto. Will ketosis compromise my body’s ability to retain the fat that is transferred as it needs to establish a new blood supply to be able to live in the new location. I am currently at my goal weight and am no longer losing weight. My initial thought is that since ketosis is a healthy state for the body to be in, it should not be a problem. But what say you?


Jan 24, 2019

In this episode, Jimmy and Dr. Will Cole answer your questions about Jillian Michaels, HPV And Keto, Weight Loss After Cancer, Coming Off Statins, Getting Cancer While Eating Keto, Longevity Studies Of Ketosis and more!

Jillian Michaels criticizes keto diet: 'Why would anyone think this is a good idea?'


1. If I have hemochromatosis, then how do I lower iron and Vitamin C while eating keto? 

2. What level of total cholesterol is considered “too high” when you eat keto?

3. Is getting adequate fiber eating keto the key to lowering visceral fat?

4. Can someone with kidney disease eat a ketogenic diet without fear of more damage?

5. Is eating low-carb fermented foods the best way to heal the gut while eating keto?

Jimmy and Will answer your questions:

- Is cycling between ketogenic diet and eating carbs what led to the HPV? Will keto help or hinder my goal of getting rid of this?

- What can I do in my keto diet to make weight loss happen again after cancer treatments?

- Can statins stall weight loss on keto? What should a keto dieter coming off a statin medication be concerned with to track their heart health?

- Is keto the answer for cancer if someone develops it while eating a strict ketogenic diet?

- Are there studies looking at the longevity effects of keto that are compelling like the ones presented by the blue zone people groups such as the Adventists?

Find full show notes here

Jan 17, 2019

In this episode, Jimmy and Dr. Will Cole answer your questions about Keto Causing Weight Gain, Antibiotics Lower Ketones, Sleep And Hormones, Depo Birth Control Shot While Keto, Feeling Better On Hypocaloric Keto and more!


1. The Keto-Mojo blood ketone meter shows readings for hematocrit and hemoglobin—how do these relate to glucose, ketones, and overall health?

2. Does the constant “ping” we get from our devices trigger a cortisol response that could sabotage your ability to get into ketosis and reap its benefits?

3. What are the pros and cons of choosing not to exercise the first couple of months after you start keto?

4. If a woman eating keto gets pregnant, what benefits will she see remaining in ketosis vs. not being in ketosis?

5. As a former vegan pursuing nutritional ketosis, how do I switch over my mentality that cooked meat is “dead food” and embrace it as healthy now?

Jimmy and Will answer your questions:

  • Could keto and fasting be the reason why someone is struggling with weight loss?
  • Do antibiotics lower ketone production and how can I heal the damage they are doing to my gut health?
  • Could my sleep issues that were diagnosed as being caused by fibromyalgia actually be related more to hormones that a ketogenic diet is helping me bring under control?
  • Why does taking a birth control shot like Depo increase hunger and moodiness despite being in a ketogenic state?
  • Why do I feel better eating 800 calories vs. 1800 calories of keto meals?

Find full show notes here

Jan 10, 2019

Welcome back to Keto Talk! We're back for a dynamic 2019, and if there's ever been the Year of Keto, this is it! Find out what Jimmy and Will have been up to over the break and where they see Keto going in 2019. In this episode, Jimmy and Dr. Will Cole answer your questions about Too High LDL Cholesterol, Gut Dysbiosis, Best Genetic Tests, Hysterectomy And Mental Health Medications, Keto Feeding Eating Disorders, and more!


  1. Do skin tags go completely away for good once you’ve healed insulin resistance?
  2. If fasting increases human growth hormone, then can you build muscle while fasting?
  3. Can getting into ketosis be a part of the cure for Hepatitis C?
  4. How does someone with pancreatitis do the high-fat part of a ketogenic diet?
  5. What factors determine when you need to possibly shift your keto routine?

Jimmy and Will answer your questions:

– Is there any such thing as “too high” LDL cholesterol to become worried?
– Is there any such thing as “too high” LDL cholesterol to become worried?
– What genetic test should I run to determine how best to eat for my gene variants?
– Can a hysterectomy and mental health drugs lead to weight gain despite ketosis?
– Does someone with an eating disorder make their problem worse by going keto?

Find full show notes here: [blog post url]